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Growth hormone response in low-dose apomorphine test correlates with nigrostriatal dopamine transporter binding in patients with Parkinson's disease.

Author: BaierP C, HappeS, HelmschmiedK, KochW, MellerJ, PaulusW, TatschK, TingsT, TrenkwalderC, WelschJ, WuttkeW

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Challenge with low-dose apomorphine can be used as an indirect tool to measure the extent of nigrostriatal neurodegeneration in early Parkinson's disease.
Paper Details　
Original Abstract of the Article :
Challenge with low-dose apomorphine causes a rise in growth hormone (GH) in patients with Parkinson's disease (PD). We studied 18 patients with early PD, who showed an increase of GH in the low-dose apomorphine test, by means of [(123)I] FP-CIT-SPECT. The mean specific dopamine transporter binding o...See full text at original site
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引用元：
https://doi.org/10.1007/s00702-006-0611-6

データ提供：米国国立医学図書館（NLM）

Parkinson's Disease: A Desert of Degeneration

This research delves into the intricate world of Parkinson's disease, a neurodegenerative disorder that affects movement and coordination. The researchers embarked on a journey to explore the relationship between dopamine transporter binding, a marker of nerve cell degeneration, and the growth hormone response to low-dose apomorphine, a medication commonly used to treat Parkinson's. It was like charting a course through a desert landscape, seeking to understand the progression of this challenging condition.

Mapping the Desert

The study found a significant negative correlation between the increase in growth hormone after apomorphine administration and the amount of dopamine transporter binding in the brain. This discovery was like finding a trail marker in the desert, providing valuable insights into the extent of neurodegeneration. It suggests that low-dose apomorphine challenge could potentially serve as an indirect tool to measure the severity of Parkinson's disease in its early stages.

Navigating the Sands of Parkinson's

This research offers a valuable tool for understanding and managing Parkinson's disease. By understanding the relationship between dopamine transporter binding and growth hormone response, researchers can potentially gain a better understanding of disease progression and develop more effective treatment strategies. The study emphasizes the importance of continuous research to navigate the complex desert of neurodegenerative disorders.

Dr. Camel's Conclusion

This study demonstrates the potential use of low-dose apomorphine challenge as an indirect tool to measure the severity of Parkinson's disease in its early stages. The correlation between growth hormone response and dopamine transporter binding provides valuable insights into the progression of neurodegeneration, offering potential for improved disease management and therapeutic strategies.
Date :
  1. Date Completed 2007-10-09
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

17187291

DOI: Digital Object Identifier

10.1007/s00702-006-0611-6

Related Literature

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・Effects of apomorphine injection
SNS
PICO Info
in preparation
Languages

English

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