Modulation of human BCRP (ABCG2) activity by anti-HIV drugs.

Author: EfferthThomas, HaefeliWalter Emil, Ketabi-KiyanvashNahal, RoseJohanna, SauerAlexandra, StorchCaroline Henrike, WeissJohanna

Paper Details 
Original Abstract of the Article :
The safety and effectiveness of highly active antiretroviral therapy (HAART) is challenged by viral resistance to antiretrovirals and the frequent occurrence of drug interactions which may limit the access of these drugs to the target sites. In particular, drug distribution and elimination may be mo...See full text at original site
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引用元:
https://doi.org/10.1093/jac/dkl474

データ提供:米国国立医学図書館(NLM)

HIV Treatment: A Tightrope Walk Across a Desert of Drug Interactions

The fight against HIV is a relentless journey through a vast desert of drug interactions, where the delicate balance between safety and effectiveness is constantly being challenged. This study delves into the complexities of [研究分野] by exploring the interactions between anti-HIV drugs and a crucial efflux transporter known as BCRP. Researchers used [研究手法] to investigate how various anti-HIV drugs affect BCRP activity, aiming to [主な目的] and gain a deeper understanding of their impact on drug distribution and elimination. The results unveiled a complex interplay between these drugs and BCRP, highlighting the potential for drug interactions to affect therapeutic efficacy.

A Complex Interplay: Anti-HIV Drugs and BCRP

The researchers discovered that anti-HIV drugs can [研究結果] in various ways, impacting the activity of BCRP. This revelation underscores the need for careful consideration of drug interactions when developing HIV treatment regimens, as such interactions can significantly influence drug efficacy and patient outcomes. Further research is needed to fully understand the intricacies of these interactions and optimize therapeutic strategies for HIV patients.

Navigating the Desert of Drug Interactions

The study serves as a reminder of the complexity of HIV treatment and the importance of navigating the desert of drug interactions with caution. By understanding the potential interplay between anti-HIV drugs and BCRP, clinicians can make more informed decisions about treatment regimens and ensure optimal patient outcomes.

Dr. Camel's Conclusion

Like a camel navigating a vast desert, HIV treatment requires careful consideration of the many factors involved, including potential drug interactions. This study sheds light on the complex relationship between anti-HIV drugs and BCRP, highlighting the importance of personalized medicine and ongoing research in this field.

Date :
  1. Date Completed 2007-03-22
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

17202245

DOI: Digital Object Identifier

10.1093/jac/dkl474

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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