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Trifluoperazine causes a disturbance in glycerophospholipid monolayers containing phosphatidylserine (PS): effects of pH, acyl unsaturation, and proportion of PS.
Author: BroniecAgnieszka, GjerdeAnja Underhaug, HolmsenHolm, ØlmheimAnne Berit
Original Abstract of the Article :
We have studied the interaction of trifluoperazine (TFP) with monolayers of various glycerophospholipids at 37 degrees C. TFP (1-10 microM) had little effect on surface pressure/molecular area isotherms in monolayers (on pure water) of dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidy...See full text at original site
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引用元:
https://doi.org/10.1021/la061628b
データ提供:米国国立医学図書館(NLM)
Trifluoperazine's Impact on Cell Membranes: Unraveling the Interaction
The field of [pharmacology] is constantly seeking to understand how medications interact with the body at a cellular level. This study delves into the interaction between [trifluoperazine] and various [glycerophospholipids], the building blocks of cell membranes.
The researchers meticulously investigated the effects of trifluoperazine on the structure and properties of [lipid monolayers], mimicking the cell membrane environment. Their findings reveal the significant influence of trifluoperazine on the organization and behavior of these lipids, particularly in the presence of [phosphatidylserine (PS)], a crucial component of cell membranes.
A Molecular Dance: Trifluoperazine and Cell Membranes
This research provides valuable insights into the complex interactions between trifluoperazine and cell membranes. The findings highlight the [electrostatic interactions] between the drug and the lipid headgroups, as well as the potential for [insertion of the drug molecule] into the lipid bilayer. These interactions are crucial for understanding the [pharmacological activity] of trifluoperazine and its potential effects on cellular function.
Understanding Drug Action: A Molecular Perspective
This research emphasizes the importance of examining drug interactions at the molecular level to fully understand their therapeutic effects. By studying the intricacies of how drugs interact with cell membranes, we gain valuable insights into [drug efficacy, safety, and potential side effects]. This knowledge is crucial for developing new and improved medications.
Dr.Camel's Conclusion
Just as a camel navigates the desert landscape, trifluoperazine interacts with the intricate world of cell membranes. This research delves into the molecular dance between this drug and the lipids that form our cells, revealing insights into the mechanisms underlying drug action. This detailed understanding is essential for developing safe and effective therapies that target specific cellular processes.
Date :
- Date Completed 2007-07-17
- Date Revised 2013-11-21
Further Info :
Related Literature
English
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