Effects of capsaicin on intestinal cephalexin absorption in rats.

Author: AibaTetsuya, KawasakiHiromu, KomoriYukiko, KurosakiYuji, NakaiChie, SugiyamaRisa

Paper Details 
Original Abstract of the Article :
The effects of capsaicin on intestinal cephalexin absorption were investigated by means of in situ single pass perfusion in rats to clarify whether this pungent compound present in spice is a potential factor altering the intestinal drug absorption processes. Under the control condition, cephalexin ...See full text at original site
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引用元:
https://doi.org/10.1248/bpb.30.547

データ提供:米国国立医学図書館(NLM)

Capsaicin: A Spice with a Complex Impact on Drug Absorption

The world of [drug absorption] is a complex one, influenced by various factors, including dietary components. This study investigates the impact of capsaicin, a pungent compound found in spices, on intestinal cephalexin absorption in rats. The researchers used an in situ single pass perfusion model to evaluate the effects of capsaicin on cephalexin absorption in different sections of the intestine. They found that capsaicin significantly reduced cephalexin absorption, suggesting that this spice can alter intestinal drug transport mechanisms. The study also explored the potential involvement of transient receptor potential (TRP) cation channels in capsaicin's effects on cephalexin absorption, highlighting the complex interplay of dietary components and drug transport processes.

Capsaicin: A Spicy Twist on Drug Absorption

This study reveals the intriguing impact of capsaicin on intestinal drug absorption, highlighting the importance of considering dietary factors in drug pharmacokinetics. It's like adding a spicy twist to a traveler's desert journey, where the addition of a new ingredient can significantly alter the course of the expedition. The researchers' findings underscore the complexity of drug absorption and the potential for dietary components to modify drug transport processes, adding a new dimension to our understanding of drug efficacy and safety.

Navigating the Desert of Drug Absorption

This research emphasizes the importance of understanding the complex interplay of dietary components and drug absorption. It's like navigating a vast and ever-shifting desert landscape, where a small change in the terrain can have a significant impact on the journey's success. The researchers' findings highlight the need for further research to understand the potential interactions between dietary components and drugs, ensuring optimal drug efficacy and safety for all patients.

Dr. Camel's Conclusion

This study reveals the intriguing impact of capsaicin on intestinal drug absorption, highlighting the complexity of drug transport processes and the need for further research to understand the potential interactions between dietary components and drug efficacy.

Date :
  1. Date Completed 2007-08-20
  2. Date Revised 2019-07-20
Further Info :

Pubmed ID

17329854

DOI: Digital Object Identifier

10.1248/bpb.30.547

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English

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