Synergistic vascular protective effects of combined low doses of PPARalpha and PPARgamma activators in angiotensin II-induced hypertension in rats.

Author: AmiriF, CohnJ S, De CiuceisC, IglarzM, SchiffrinE L, TouyzR M

Paper Details 
Original Abstract of the Article :
Protective cardiovascular effects of peroxisome proliferator activated receptor (PPAR)alpha and PPARgamma activators have been demonstrated. If used as vasoprotective agents in high risk vascular patients rather than for their metabolic benefits, these agents could be associated with unwanted side e...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2012983/

データ提供:米国国立医学図書館(NLM)

PPARalpha and PPARgamma: A Collaborative Journey Through the Desert of Hypertension

Hypertension, a condition characterized by high blood pressure, poses a significant risk factor for cardiovascular disease. This research explores the potential benefits of combining low doses of PPARalpha and PPARgamma activators, like a caravan traveling with multiple resources and a collaborative approach, to protect against hypertension-related damage. Imagine a caravan traversing a desert where the heat and sun can take a toll on the travelers. PPARalpha and PPARgamma, like essential supplies and strategic planning, offer potential protection against the harmful effects of hypertension.

PPARalpha and PPARgamma: A Synergistic Approach in the Desert of Vascular Health

The researchers found that combining low doses of PPARalpha and PPARgamma activators provided vascular protective benefits similar to full doses of these agents. This is like having a caravan with multiple resources and a well-coordinated plan, maximizing efficiency and effectiveness while minimizing risks. The study suggests that this synergistic approach could be beneficial for high-risk vascular patients, offering a potentially more effective and safer way to manage hypertension.

Navigating the Desert of Cardiovascular Care

This research highlights the potential benefits of combining low doses of PPARalpha and PPARgamma activators, like a well-equipped caravan with a collaborative approach, to manage hypertension. It suggests that this strategy could be beneficial for high-risk patients, offering a more effective and potentially safer way to navigate the desert of cardiovascular care. However, as with any desert journey, it's crucial to consult with your doctor to determine the best course of treatment for your individual needs, ensuring a safe and successful journey towards better cardiovascular health.

Dr.Camel's Conclusion

This research offers a valuable perspective on hypertension management, comparing the combination of PPARalpha and PPARgamma to a well-coordinated caravan with a collaborative approach. It suggests that this synergistic strategy could offer a more effective and potentially safer way to navigate the desert of cardiovascular health. As we continue to explore the complexities of cardiovascular disease, we can learn from this research and develop innovative strategies to improve outcomes for those facing the challenges of hypertension.
Date :
  1. Date Completed 2007-07-27
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

17351653

DOI: Digital Object Identifier

PMC2012983

Related Literature

SNS
PICO Info
in preparation
Languages

English

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