Paper Details

  1. Home
  2. Paper Details

Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam--probes of CYP2C9, CYP1A2, and CYP3A4.

Author: BackmanJ T, LiljaJ J, NeuvonenP J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effects of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam. Daily ingestion of cranberry juice did not inhibit the activities of CYP2C9, CYP1A2, or CYP3A4, suggesting that a pharmacokinetic mechanism for the cranberry juice-warfarin interaction is unlikely.
Paper Details　
Original Abstract of the Article :
Case reports suggest that cranberry juice can increase the anticoagulant effect of warfarin. We investigated the effects of cranberry juice on R-S-warfarin, tizanidine, and midazolam; probes of CYP2C9, CYP1A2, and CYP3A4. Ten healthy volunteers took 200 ml cranberry juice or water t.i.d. for 10 days...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1038/sj.clpt.6100149

データ提供：米国国立医学図書館（NLM）

Cranberry Juice: A Curious Oasis in the Desert of Drug Interactions

The world of drug interactions is a complex and often confusing desert, filled with unexpected twists and turns. This 2007 study investigated the effects of cranberry juice on the pharmacokinetics of three common drugs - warfarin, tizanidine, and midazolam. It's like a camel caravan exploring a new route through the desert, seeking to understand how different elements interact with each other. The study found that daily ingestion of cranberry juice did not significantly inhibit the activities of the enzymes involved in metabolizing these drugs. This discovery is like finding a clear path through the desert, offering a sense of certainty in an otherwise unpredictable landscape.

A Lack of Significant Interaction

The study showed that cranberry juice did not significantly affect the pharmacokinetic profiles of warfarin, tizanidine, and midazolam. This is like finding a well that doesn't dry up in the desert, providing a consistent source of hydration. It's good news for those who enjoy cranberry juice and also take these medications, as it suggests that there is no significant interaction between these two.

Understanding the Desert of Drug Interactions

This study reminds us that the world of drug interactions is a complex desert, with many factors to consider. It's important to be mindful of potential interactions and consult with a healthcare professional. This study serves as a valuable reminder that we need to be vigilant and explore the desert carefully to understand the dynamics of drug interactions.

Dr.Camel's Conclusion

This study provides a valuable insight into the potential interactions between cranberry juice and certain medications. It's like finding a safe and clear path through the desert of drug interactions, offering reassurance to those who enjoy cranberry juice and take these medications.

Date :
  1. Date Completed 2007-07-27
  2. Date Revised 2018-12-11
Further Info :

Pubmed ID

17392729

DOI: Digital Object Identifier

10.1038/sj.clpt.6100149

Related Literature

Article Analysis
・Effects of tizanidine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.