Paper Details

  1. Home
  2. Paper Details

Comparison of the effects of thioridazine and mesoridazine on the QT interval in healthy adults after single oral doses.

Author: McKayG A, SalihI S M, ThanacoodyR H K, ThomasS H L

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study compared the effects of single doses of thioridazine and mesoridazine on the heart rate-corrected QT (QTc) interval in healthy volunteers. Both drugs were associated with similar effects on the QTc interval.
Paper Details　
Original Abstract of the Article :
We compared the effects of single doses of thioridazine and mesoridazine on the heart rate-corrected QT (QTc) interval in healthy adult volunteers. QTc intervals and plasma concentrations of thioridazine, mesoridazine, and metabolites were measured after single oral doses of thioridazine hydrochlori...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1038/sj.clpt.6100194

データ提供：米国国立医学図書館（NLM）

Comparing Thioridazine and Mesoridazine's Effects on the QT Interval

This study, akin to a camel carefully navigating the delicate balance of [cardiac health], investigates the effects of two antipsychotic drugs, [thioridazine] and [mesoridazine], on the [QT interval] in healthy adult volunteers. The researchers measured the [QTc interval], which reflects the duration of the heart's repolarization, after administering single oral doses of each drug and a placebo.

Similar Effects on the QT Interval

The study found that both [thioridazine] and [mesoridazine] led to similar increases in the [QTc interval], significantly greater than those observed with the placebo. This finding suggests that both drugs have a comparable impact on the heart's electrical activity.

Navigating the Terrain of Cardiac Safety

This research highlights the importance of considering potential cardiac effects when prescribing medications, particularly those that can affect the [QT interval]. It emphasizes the need for careful monitoring of patients receiving these medications to minimize risks.

Dr.Camel's Conclusion

This study reveals that both thioridazine and mesoridazine, while effective in treating certain conditions, can significantly prolong the QT interval, a measure of the heart's electrical activity. This research underscores the importance of careful monitoring of patients receiving these medications to ensure their cardiac safety.

Date :
  1. Date Completed 2007-11-28
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

17410120

DOI: Digital Object Identifier

10.1038/sj.clpt.6100194

Related Literature

Article Analysis
・Effects of thioridazine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.