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Evaluation of in vitro release and in vivo efficacy of mPEG-PLA-haloperidol conjugate micelle-like structures.

Author: EhrlichmanRichard S, HansMeredith L, LiangYuling, LowmanAnthony M, MaxwellChristina, MetzgerKayla, SiegelSteven J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

This study investigates the properties of polymeric prodrugs of mPEG-PLA-haloperidol, which self-assemble into nanoscale micelle-like structures. These micelles exhibit controlled drug release over a period of days, potentially reducing the sedative side effects of haloperidol compared to acute injections.
Paper Details　
Original Abstract of the Article :
Polymeric prodrugs of mPEG-PLA-haloperidol (methoxy poly(ethylene glycol)-b-poly (lactic acid)), self-assemble into nanoscale micelle-like structures in aqueous solutions. The micelles range in size from 28 to 52 nm in diameter and have been shown to be spherical in shape using cryogenic transmissio...See full text at original site
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引用元：
https://doi.org/10.1002/jbm.b.30812

データ提供：米国国立医学図書館（NLM）

Delivering Haloperidol: A New Approach to Treatment

Haloperidol is a medication used to treat various psychiatric conditions, including schizophrenia and bipolar disorder. However, it can have significant side effects, including sedation and movement problems. This study investigates the potential benefits of delivering haloperidol in a new form: as micelle-like structures composed of methoxy poly(ethylene glycol)-b-poly(lactic acid) (mPEG-PLA). The researchers found that these micelle-like structures could effectively deliver haloperidol and reduce its sedative side effects. They also found that the micelle-like structures prolonged the release of haloperidol, which could lead to improved treatment efficacy.

Micelle-Like Structures: A New Route for Drug Delivery

This study explores the potential of micelle-like structures as a novel drug delivery system. It's like finding a new caravan route through the desert that allows you to travel more efficiently and safely. The researchers found that these micelle-like structures could effectively deliver haloperidol while reducing its sedative side effects. They also observed a prolonged release profile, which could lead to better therapeutic outcomes.

Haloperidol: A Challenging Journey

Haloperidol is a valuable medication for treating certain psychiatric conditions, but its side effects can be challenging. This study suggests that delivering haloperidol in a new form, such as micelle-like structures, could improve the treatment experience for patients. It's like finding a way to make the journey through the desert smoother and more comfortable.

Dr. Camel's Conclusion

Micelle-like structures offer a potential new route for delivering haloperidol, like a hidden oasis in the desert of drug delivery research. The study suggests that this new approach could lead to improved therapeutic outcomes and reduced side effects for patients. Further research is needed to confirm these findings and explore the full potential of micelle-like structures for drug delivery.

Date :
  1. Date Completed 2007-12-27
  2. Date Revised 2020-09-30
Further Info :

Pubmed ID

17415770

DOI: Digital Object Identifier

10.1002/jbm.b.30812

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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