Isoflurane-delayed preconditioning reduces immediate mortality and improves striatal function in adult mice after neonatal hypoxia-ischemia.

Author: JosephBernadin, McAuliffeJohn J, VorheesCharles V

Paper Details 
Original Abstract of the Article :
Exposure to hypoxia and isoflurane (Iso) before hypoxia-ischemia has been found to be neuroprotective in neonatal rats. We investigated the long-term effects of delayed preconditioning with Iso, hypoxia, or room air on motor and cognitive function in mice that had 65 min of hypoxia-ischemia on postn...See full text at original site
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引用元:
https://doi.org/10.1213/01.ane.0000260321.62377.74

データ提供:米国国立医学図書館(NLM)

A Race Against Time: Protecting the Brain After Neonatal Hypoxia-Ischemia

The delicate brain of a newborn is particularly vulnerable to the effects of [hypoxia-ischemia], a condition where the brain is deprived of oxygen. This research focuses on the potential benefits of [isoflurane-delayed preconditioning] in mitigating the long-term consequences of neonatal hypoxia-ischemia. The study investigated the effects of delayed preconditioning with [isoflurane], [hypoxia], or [room air] on the motor and cognitive function of mice exposed to hypoxia-ischemia on postnatal day 10. The results shed light on the potential neuroprotective effects of isoflurane preconditioning in the context of neonatal brain injury.

A Shield for the Brain: The Power of Isoflurane Preconditioning

The researchers found that [isoflurane-delayed preconditioning] significantly reduced [immediate mortality] and improved [striatal function] in mice that had experienced neonatal hypoxia-ischemia. This promising finding suggests that isoflurane preconditioning could potentially play a role in protecting the developing brain from the damaging effects of oxygen deprivation. While this study was conducted in mice, it provides a valuable foundation for further research into the potential benefits of isoflurane preconditioning in human infants.

A Call for Further Exploration: Protecting the Most Vulnerable

This research underscores the importance of ongoing research into potential interventions that can mitigate the long-term consequences of neonatal hypoxia-ischemia. While this study offers promising findings, more research is needed to understand the safety and efficacy of isoflurane preconditioning in human infants. It's crucial to continue seeking ways to protect the delicate brains of our most vulnerable population, ensuring they have the best possible chance at a healthy future.

Dr.Camel's Conclusion

Just as a camel endures harsh desert conditions, newborns face their own set of challenges, especially when it comes to brain development. This research provides a glimmer of hope for protecting the brains of infants who experience hypoxia-ischemia. It reminds us that even in the most vulnerable stages of life, there may be interventions that can shield us from harm. Keep pushing the boundaries of research, keep exploring new avenues, and keep striving to protect the precious brains of our youngest generation.

Date :
  1. Date Completed 2007-05-24
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

17456654

DOI: Digital Object Identifier

10.1213/01.ane.0000260321.62377.74

Related Literature

SNS
PICO Info
in preparation
Languages

English

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