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Polymorphisms of ACE2 gene are associated with essential hypertension and antihypertensive effects of Captopril in women.

Author: , ChenJ, FanX, HanY, HuiR, LiW, LiuT, SunK, WangJ, WangS, WangX, WangY, WuH, YangX, ZhangW, ZhenY

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that the ACE2 T allele was associated with a higher risk of hypertension in women, particularly when combined with the ACE DD genotype. The T allele also showed a reduced antihypertensive response to ACE inhibitors in women.
Paper Details　
Original Abstract of the Article :
ACE2 appears to counterbalance the vasopressor effect of angiotensin I converting enzyme (ACE) in the reninangiotensin system. We hypothesized that ACE2 polymorphisms could confer a high risk of hypertension and have an impact on the antihypertensive response to ACE inhibitors. The hypothesis was te...See full text at original site
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引用元：
https://doi.org/10.1038/sj.clpt.6100214

データ提供：米国国立医学図書館（NLM）

The ACE2 Gene: A Key Player in Hypertension and Antihypertensive Treatments

High blood pressure, a common health concern, is like a desert wind that relentlessly pushes against our cardiovascular system. This study delves into the world of genetics, exploring the role of the ACE2 gene in hypertension and its impact on the effectiveness of antihypertensive drugs.

ACE2: A Complex Interaction in the Desert of Hypertension

The ACE2 gene plays a delicate balancing act in the renin-angiotensin system, a complex network that regulates blood pressure. This study discovered that specific variations in the ACE2 gene, particularly the T allele of the rs2106809 polymorphism, are associated with an increased risk of hypertension in women. It's like a ripple in the desert sand, subtly affecting the delicate balance of the ecosystem.

ACE2 and Antihypertensive Response: A Personalized Approach

The study further suggests that variations in the ACE2 gene can influence the effectiveness of antihypertensive drugs. In women carrying the ACE2 T allele, Captopril, an ACE inhibitor, showed a less pronounced blood pressure-lowering effect. This finding highlights the importance of personalized medicine, where genetic variations can help tailor treatment strategies for optimal results. It's like having a custom-made camel saddle that fits perfectly, ensuring a more comfortable and effective journey.

Dr. Camel's Conclusion

This study adds another layer of complexity to our understanding of hypertension and its treatment. The ACE2 gene appears to play a significant role in the development of hypertension, particularly in women, and can influence the effectiveness of certain medications. These findings underscore the importance of personalized medicine and the need for further research to explore the intricate interplay between genetics, hypertension, and treatment responses. Remember, in the vast desert of human health, every detail, even a tiny grain of sand, can make a difference.

Date :
  1. Date Completed 2007-09-11
  2. Date Revised 2020-12-09
Further Info :

Pubmed ID

17473847

DOI: Digital Object Identifier

10.1038/sj.clpt.6100214

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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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