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A review of cis-trans interplay between DNA sequences 5' to the (G)gamma- and beta-globin genes among Hb F-Malta-I heterozygotes/homozygotes and beta-thalassemia homozygotes/compound heterozygotes, and the effects of hydroxyurea on the Hb F/F-erythrocyte; the need for large multicenter trials.

Author: BorgJoseph, CaruanaMary R, CassarWilhelmina, FarrugiaMario, FeliceAlex E, GaldiesRuth, HunterGary J, PizzutoMonica, PulisSvetlana, ScerriChristian A, WettingerStephanie Bezzina

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigates the potential of inducing Hb F synthesis as a treatment for beta hemoglobinopathies, such as beta-thalassemia. The study explores the role of the XmnI sequence and hydroxyurea (HU) in regulating Hb F levels. While HU can increase Hb F levels, its effects on circulating hemoglobin are limited. Further research is needed to develop more effective strategies for inducing and maintaining high Hb F levels.
Paper Details　
Original Abstract of the Article :
The biosynthesis of Hb F in place of the deficient Hb A could be a suitable treatment for beta hemoglobinopathies. Among newborn Hb F-Malta-I heterozygotes, it could be shown that the XmnI sequence alone had little, if any effect on gamma-globin gene expression, but interplay with the (AT)(X)T(Y) si...See full text at original site
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引用元：
https://doi.org/10.1080/03630260701297261

データ提供：米国国立医学図書館（NLM）

Hb F-Malta-I: A Potential Treatment for Beta Hemoglobinopathies

This review examines the potential of Hb F-Malta-I, a variant of fetal hemoglobin, as a treatment for beta hemoglobinopathies, a group of genetic disorders affecting red blood cell production. The authors discuss the cis-trans interplay between DNA sequences involved in Hb F-Malta-I expression and the effects of hydroxyurea on Hb F levels. The research explores the possibility of inducing higher levels of Hb F as a therapeutic strategy for these disorders.

A Potential Solution: Inducing Higher Levels of Hb F

The study highlights the potential of Hb F-Malta-I as a therapeutic target for beta hemoglobinopathies. The authors note that even small increases in Hb F levels could lead to significant improvements in clinical outcomes. The research suggests that inducing higher levels of Hb F could offer a promising therapeutic strategy for these disorders.

A Camel's Perspective: Seeking a Path to Health in Genetic Disorders

Like a camel navigating a desolate desert, researchers are seeking a path to health for individuals affected by beta hemoglobinopathies. This study explores the potential of Hb F-Malta-I as a therapeutic target, offering hope for a brighter future for those with these genetic disorders.

Dr.Camel's Conclusion

This research explores the potential of Hb F-Malta-I as a treatment for beta hemoglobinopathies. The study highlights the need for further research to better understand the mechanisms of Hb F expression and the potential of inducing higher levels of Hb F as a therapeutic strategy.

Date :
  1. Date Completed 2007-07-12
  2. Date Revised 2017-11-16
Further Info :

Pubmed ID

17486512

DOI: Digital Object Identifier

10.1080/03630260701297261

Related Literature

Article Analysis
・Effects of hydroxyurea
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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