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Advances in the pharmacologic management of early Parkinson disease.

Author: HauserRobert A, ZesiewiczTheresa A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Levodopa, combined with a dopa decarboxylase inhibitor, is the most effective treatment for Parkinson's disease (PD), offering significant symptomatic benefits with minimal short-term side effects. However, the long-term use of levodopa is associated with the development of motor fluctuations and dyskinesias, highlighting the need for further research into long-term management strategies for PD.
Paper Details　
Original Abstract of the Article :
Levodopa, in combination with a dopa decarboxylase inhibitor, provides the greatest symptomatic benefit with the fewest short-term side effects in the treatment of Parkinson disease (PD). However, the disease continues to progress, and the long-term use of levodopa is associated with the development...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/17495756

データ提供：米国国立医学図書館（NLM）

Managing Early Parkinson's Disease: A Journey Through the Desert of Symptoms

Parkinson's disease is like a slow, relentless desert wind, gradually eroding motor function and causing tremors, stiffness, and slow movements. The journey through this desert can be challenging, but researchers continue to seek ways to alleviate its symptoms. This article explores the current pharmacologic management of early Parkinson's disease, focusing on the crucial role of levodopa.

Levodopa's Impact on Parkinson's Disease

Levodopa, a medication that acts as a precursor to dopamine, is like a lifeline in the desert of Parkinson's disease. It provides the greatest symptomatic benefit with the fewest short-term side effects. However, as the disease progresses, the long-term use of levodopa can lead to motor fluctuations and dyskinesias, like a camel stumbling through a sandstorm. This highlights the need for ongoing research and development of new therapies to effectively manage Parkinson's disease.

Living with Parkinson's Disease

Parkinson's disease can be a challenging journey, but with proper management, it's possible to maintain a good quality of life. It's crucial to listen to your body and work with your healthcare provider to develop a treatment plan that meets your individual needs. Remember, even in the vastness of the desert, there are oases of support and hope. Joining support groups and connecting with others who understand the experience can provide valuable companionship and resources.

Dr.Camel's Conclusion

This research underscores the importance of continuous advancements in the treatment of Parkinson's disease. Levodopa remains a vital tool in managing symptoms, but the need for long-term strategies to prevent motor fluctuations and dyskinesias remains a pressing concern. Research is ongoing, and new discoveries are constantly emerging, like an oasis in the middle of the desert. Stay informed, seek support, and keep your spirits high as you navigate the journey through Parkinson's disease.
Date :
  1. Date Completed 2007-07-18
  2. Date Revised 2007-05-14
Further Info :

Pubmed ID

17495756

DOI: Digital Object Identifier

00127893-200705000-00003

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