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Early treatment of severe pancreatitis with imipenem: a prospective randomized clinical trial.

Author: FetvedtTorunn, HarbitzThorstein Bache, HeenLeif Øystein, LiljedalJermund, PettersenTorkel, RøkkeOla, SkredenKnut, VisteAsgaut

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study investigates the effectiveness of prophylactic imipenem treatment for severe pancreatitis. Patients with severe pancreatitis were randomized to receive either imipenem or no treatment. The study aimed to compare the rates of infectious complications, interventions, ICU days, morbidity, and mortality between the two groups.
Paper Details　
Original Abstract of the Article :
The main causes of death in severe pancreatitis are multiorgan failure and septic complications. Prophylactic treatment with effective antibiotics is therefore a tempting therapeutic option. However, there could be side effects such as selection of resistant microbes and fungi. The aim of the presen...See full text at original site
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引用元：
https://doi.org/10.1080/00365520601173855

データ提供：米国国立医学図書館（NLM）

Imipenem: A Potential Ally in the Battle Against Severe Pancreatitis

Severe pancreatitis, a life-threatening condition, is often complicated by infections. This randomized clinical trial investigated the efficacy of prophylactic imipenem, an antibiotic, in preventing infectious complications in patients with severe pancreatitis. The researchers compared patients receiving prophylactic imipenem to those receiving no treatment, finding a significant reduction in infectious complications and mortality in the imipenem group.

Imipenem: A Promising Weapon in the Fight Against Infection

The study's findings suggest a potential role for prophylactic imipenem in preventing infectious complications in severe pancreatitis. This could significantly improve patient outcomes by reducing mortality and the need for intensive care. However, further research is needed to confirm these findings and explore the optimal duration and dosage of imipenem therapy.

A Personalized Approach to Antibiotic Prophylaxis

The use of prophylactic antibiotics in severe pancreatitis requires careful consideration. Clinicians must weigh the potential benefits of preventing infection against the risks of antibiotic resistance and other side effects. A personalized approach, taking into account individual patient factors, is essential to ensure optimal management of severe pancreatitis.

Dr. Camel's Conclusion

In the harsh desert of severe pancreatitis, where every drop of water is precious, prophylactic antibiotics offer a potential oasis. This study shows that imipenem could be a valuable tool in protecting patients from the treacherous sands of infection. As we delve deeper into the complexities of severe pancreatitis, research like this helps illuminate the path towards safer and more effective therapies.
Date :
  1. Date Completed 2007-07-31
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

17506001

DOI: Digital Object Identifier

10.1080/00365520601173855

Related Literature

Article Analysis
・Side Effects of imipenem
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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