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ACP-103, a 5-hydroxytryptamine 2A receptor inverse agonist, improves the antipsychotic efficacy and side-effect profile of haloperidol and risperidone in experimental models.

Author: AndersonGary T, BaridoRichard, BonhausDouglas W, BrannMark R, BrunmarkPer, DavisRobert E, DyssegaardAgnete, GardellLuis R, HacksellUli, JohnsonRobert W, PoundsLinda, TabatabaeiAli, VanoverKimberly E, VeinbergsIsaac

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effects of a novel selective 5-HT(2A) receptor inverse agonist, ACP-103, in various models of antipsychotic activity. The study found that ACP-103 exhibited antipsychotic-like effects in these models and attenuated side effects associated with D(2) receptor antagonism, suggesting that it may be a promising adjunctive therapy for schizophrenia.
Paper Details　
Original Abstract of the Article :
Dopamine D(2) receptor antagonism contributes to the therapeutic action of antipsychotic drugs (APDs) but also produces undesirable side effects, including extrapyramidal motor deficits, cognitive dulling, and prolactinemia. The introduction of atypical APDs was a significant advancement in the trea...See full text at original site
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引用元：
https://doi.org/10.1124/jpet.107.121715

データ提供：米国国立医学図書館（NLM）

ACP-103: A Promising New Ally in the Fight Against Schizophrenia

This study investigates the potential of a novel 5-HT(2A) receptor inverse agonist, ACP-103, to improve the efficacy and side-effect profile of antipsychotic drugs. The research demonstrates that ACP-103, when combined with traditional antipsychotics like haloperidol and risperidone, enhances antipsychotic efficacy while reducing adverse effects associated with dopamine D(2) receptor antagonism. These findings suggest that ACP-103 could be a valuable adjunct therapy for schizophrenia, providing a more targeted and potentially safer treatment approach.

A Sun-Drenched Path: New Hope for Schizophrenia Treatment

This study illuminates a sun-drenched path towards potentially improved treatment for schizophrenia. The synergistic effects of ACP-103, when combined with traditional antipsychotics, offer a beacon of hope for patients seeking relief from the debilitating symptoms of this disorder. The research highlights the importance of innovative approaches and the potential for targeted therapies to optimize treatment outcomes and enhance patient well-being.

A Desert Bloom: Reducing Side Effects

This research is like a rare desert bloom, offering a new approach to antipsychotic treatment that could potentially reduce side effects associated with traditional therapies. The study emphasizes the importance of balancing efficacy with safety in the treatment of schizophrenia, aiming to improve both symptom control and patient quality of life.

Dr.Camel's Conclusion

This study explores the potential of ACP-103 as a novel therapeutic agent for schizophrenia, highlighting the promise of synergistic approaches to enhance antipsychotic efficacy while minimizing unwanted side effects. The research offers a glimmer of hope for a future where schizophrenia treatment is both effective and well-tolerated, leading to improved outcomes and a better quality of life for those living with this complex disorder.

Date :
  1. Date Completed 2007-09-20
  2. Date Revised 2016-11-24
Further Info :

Pubmed ID

17519387

DOI: Digital Object Identifier

10.1124/jpet.107.121715

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