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Early assessment of therapy response in malignant lymphoma with the thymidine analogue [18F]FLT.

Author: BommerMartin, BuckAndreas K, GlattingGerhard, JuweidMalik, KratochwilClemens, MattfeldtTorsten, MöllerPeter, NeumaierBernd, ReskeSven N, TepsicDjurdja, VoggAndreas T J

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

[(18)F]FLT detected early antiproliferative drug activity before changes in tumor size were visible in a lymphoma xenotransplant model.
Paper Details　
Original Abstract of the Article :
PURPOSE: The aim of this study was to determine whether the thymidine analogue 3'-deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT) is adequate for early evaluation of the response of malignant lymphoma to antiproliferative treatment in a mouse xenotransplant model. METHODS: Immunodeficient mice bearing...See full text at original site
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引用元：
https://doi.org/10.1007/s00259-007-0452-z

データ提供：米国国立医学図書館（NLM）

Early Detection of Lymphoma Response: A Timely Oasis in the Desert

Imagine a hidden oasis in the desert, only detectable by a keen eye and a special tool. That's what this research is like, exploring a new approach to detect how well lymphoma responds to treatment early on. They tested a radioactive tracer called [(18)F]FLT, which is like a glowing beacon, revealing the activity of cancerous cells. The study showed that this tracer could detect changes in the growth of lymphoma cells before any visible changes in tumor size. This early detection could potentially lead to more personalized and effective treatment strategies.

Early Detection: A Key to Effective Treatment

The study found that [(18)F]FLT can detect changes in the growth of lymphoma cells before any visible changes in tumor size. This early detection could potentially lead to more personalized and effective treatment strategies.

Hope for Improved Lymphoma Treatment

The research suggests that [(18)F]FLT could be a valuable tool for monitoring lymphoma treatment and potentially improving patient outcomes. Further research is needed to confirm its efficacy in clinical settings.

Dr.Camel's Conclusion

Navigating the treacherous desert of lymphoma requires a keen eye and the right tools. This research explored [(18)F]FLT, a special beacon, revealing the activity of cancerous cells like a hidden oasis. The early detection capabilities of this tracer, like a wise camel sensing the presence of water, could lead to more effective treatment strategies and potentially save lives.

Date :
  1. Date Completed 2008-02-06
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

17541585

DOI: Digital Object Identifier

10.1007/s00259-007-0452-z

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