Paper Details

  1. Home
  2. Paper Details

Antimyeloma effects of arsenic trioxide are enhanced by melphalan, bortezomib and ascorbic acid.

Author: BaritakiStavroula, BerensonJames R, BonavidaBenjamin, CampbellRichard A, ChenHaiming, GordonMelinda, PangShen, SaidJonathan, SanchezEric, ShalitinDror, SteinbergJeffrey A, WangCathy

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Arsenic trioxide (ATO) combined with other antimyeloma agents, such as bortezomib, melphalan, or ascorbic acid (AA), demonstrated synergistic antimyeloma effects both in vitro and in vivo. This combination therapy showed marked suppression of tumor growth and reduced serum paraprotein levels in mice with multiple myeloma.
Paper Details　
Original Abstract of the Article :
Arsenic trioxide (ATO) induces apoptosis of malignant plasma cells through multiple mechanisms, including inhibition of DNA binding by nuclear factor kappa-B, a key player in the development of chemoresistance in multiple myeloma (MM). This activity suggests that ATO may be synergistic when combined...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1111/j.1365-2141.2007.06675.x

データ提供：米国国立医学図書館（NLM）

Enhanced Antimyeloma Effects of Arsenic Trioxide

This research explores the potential for enhancing the antimyeloma effects of arsenic trioxide (ATO) by combining it with other antimyeloma agents, such as melphalan, bortezomib, and ascorbic acid (AA). The study investigates the synergistic activity of these combinations both in vitro and in vivo, using a severe combined immunodeficient (SCID)-hu murine myeloma model. The study aims to identify potential combination therapies that could improve outcomes for patients with multiple myeloma (MM).

Synergistic Activity of ATO Combinations

This research demonstrates the potential for synergistically enhancing the antimyeloma effects of arsenic trioxide (ATO) by combining it with other antimyeloma agents. The study found that combining ATO with either bortezomib or melphalan and AA significantly suppressed tumor growth and reduced serum paraprotein levels in a murine myeloma model. This suggests that these combinations could offer a more effective treatment strategy for MM.

Improving Treatment Outcomes for Multiple Myeloma

This research offers promising insights into the potential for combination therapy to improve treatment outcomes for patients with multiple myeloma (MM). The study's findings suggest that combining ATO with other antimyeloma agents could lead to more effective tumor suppression and potentially better long-term outcomes for patients. This is like discovering a new oasis in the desert of MM treatment, offering a more robust and effective strategy for combating this challenging disease.

Dr. Camel's Conclusion

This research highlights the potential for combination therapy to improve treatment outcomes for multiple myeloma (MM). It's like discovering a new oasis in the desert of MM treatment, offering a more robust and effective strategy for combating this challenging disease. This research underscores the importance of exploring innovative treatment approaches and combining different therapies to optimize outcomes for patients with MM.
Date :
  1. Date Completed 2007-09-28
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

17587338

DOI: Digital Object Identifier

10.1111/j.1365-2141.2007.06675.x

Related Literature

Article Analysis
・Effects of melphalan
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.