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HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells.

Author: ChangSandy Y, CoffinierCatherine, FarberEmily A, FongLoren G, HrycynaChristine A, HudonSarah E, YoungStephen G

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

HIV protease inhibitors (HIV-PIs) can cause an accumulation of prelamin A, which could play a role in the side effects of these drugs.
Paper Details　
Original Abstract of the Article :
HIV protease inhibitors (HIV-PIs) target the HIV aspartyl protease, which cleaves the HIV gag-pol polyprotein into shorter proteins required for the production of new virions. HIV-PIs are a cornerstone of treatment for HIV but have been associated with lipodystrophy and other side effects. In both h...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1948915/

データ提供：米国国立医学図書館（NLM）

HIV Protease Inhibitors: A Double-Edged Sword?

HIV protease inhibitors (HIV-PIs) are crucial for the treatment of HIV infection, but they can also cause side effects. This research investigates a potential mechanism underlying these side effects, specifically focusing on the accumulation of prelamin A, a protein involved in nuclear structure, in response to HIV-PI treatment.

HIV-PIs' Impact on Prelamin A Accumulation

The study found that HIV-PIs inhibited the processing of prelamin A, leading to its accumulation in cells. This accumulation was particularly pronounced in fibroblasts heterozygous for Zmpste24 deficiency, a gene involved in the processing of prelamin A. The authors concluded that HIV-PIs inhibit the enzyme ZMPSTE24, which is responsible for the final step in prelamin A processing, leading to its accumulation. This finding suggests that the inhibition of ZMPSTE24 by HIV-PIs could contribute to the side effects of these drugs.

Understanding the Potential Side Effects of HIV-PIs

This research provides crucial insights into the potential side effects of HIV-PIs, highlighting the importance of understanding their impact on cellular processes. The study's findings suggest that the accumulation of prelamin A in response to HIV-PI treatment might play a role in the development of lipodystrophy and other side effects. Further research is needed to confirm this link and explore strategies to mitigate these side effects.

Dr.Camel's Conclusion

Imagine HIV-PIs as powerful desert winds capable of clearing the path for a healthier life. However, these winds can sometimes carry unexpected sandstorms, in this case, the accumulation of prelamin A. This research sheds light on the potential side effects of these powerful medications, reminding us that even the most effective remedies can have unforeseen consequences. Understanding these complexities is crucial for guiding safe and effective HIV treatment.

Date :
  1. Date Completed 2007-10-24
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

17652517

DOI: Digital Object Identifier

PMC1948915

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