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Predictors of side effects associated with lithium administration in children.

Author: CampbellM, GonzalezN M, KafantarisV, LeeD, LocascioJ J, LynchN S, SilvaR R

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

A pooled analysis of three controlled and double-blind studies involving 48 hospitalized children with conduct disorder revealed that younger children experienced more side effects associated with lithium administration than older children. This relationship remained statistically significant after adjusting for factors such as weight, serum lithium levels, optimal dose, and duration of optimal dose.
Paper Details　
Original Abstract of the Article :
Data were pooled from three controlled and double-blind studies of lithium carbonate involving a total of 48 hospitalized children, and secondary data analyses were conducted. The objective was to assess whether there is a relationship between a child's chronological age and side effects associated ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1775612

データ提供：米国国立医学図書館（NLM）

Lithium Side Effects in Children

Lithium carbonate, a commonly used medication for treating bipolar disorder, can have side effects, particularly in children. This study investigated the relationship between a child's age and the occurrence of side effects associated with lithium administration. The authors pooled data from three controlled and double-blind studies involving hospitalized children diagnosed with conduct disorder, analyzing the number of side effects and episodes of side effects experienced by each child.

Age and Lithium Side Effects

The analysis revealed a significant association between younger age and a higher incidence of side effects. This relationship remained even after adjusting for factors such as weight, serum lithium levels, optimal dose, and duration of optimal dose. The study's findings suggest that younger children may be more susceptible to experiencing side effects from lithium treatment.

Implications for Lithium Therapy in Children

This research underscores the importance of carefully monitoring children receiving lithium treatment for potential side effects. It highlights the need for individualized approaches to lithium therapy, considering the child's age and other relevant factors to minimize the risk of adverse events. Further research is necessary to better understand the mechanisms underlying the age-related differences in lithium side effects.

Dr.Camel's Conclusion

Imagine a caravan traveling through the desert, with lithium acting as the guide, leading the way towards wellness. However, for younger travelers, the journey might be more bumpy, with a higher chance of encountering side effects along the way. This research reminds us that navigating the desert of mental health requires careful attention to each traveler's age and unique needs.

Date :
  1. Date Completed 1992-03-02
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

1775612

DOI: Digital Object Identifier

1775612

SNS
PICO Info
in preparation
Languages

English

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