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Photoaddition of fluphenazine to nucleophiles in peptides and proteins. Possible cause of immune side effects.
Author: CaffieriSergio, DalzoppoDaniele, MioloGiorgia, SeragliaRoberta, TomaFrancesca M, van HenegouwenGerard M J Beyersbergen
Original Abstract of the Article :
By the action of UVA light, fluphenazine reacted with nucleophiles through a mechanism involving defluorination of its trifluoromethyl group, giving rise to carboxylic acid derivatives that were easily detected by electrospray mass spectrometry. This photoreaction took place with alcohols, sulphydry...See full text at original site
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引用元：
https://doi.org/10.1021/tx700123u
データ提供：米国国立医学図書館（NLM）
Unveiling the Mystery Behind Fluphenazine's Immune Side Effects: A Photochemical Reaction
In the realm of [pharmacology], understanding the mechanisms behind [drug side effects] is crucial. This research dives deep into the potential cause of [immune side effects] associated with [fluphenazine], a commonly used [antipsychotic medication]. The researchers uncovered a fascinating photochemical reaction involving [fluphenazine] and [nucleophiles] in [peptides] and [proteins], shedding light on the potential for [antibody formation] and subsequent [immune system dysfunction].
Fluphenazine's Photochemical Reactivity and Potential for Immune Reactions
The study revealed that upon exposure to [UVA light], [fluphenazine] undergoes a [photochemical reaction] with [nucleophiles] in [peptides] and [proteins]. This process involves [defluorination] of the [trifluoromethyl group], leading to the formation of [carboxylic acid derivatives]. The researchers observed that this reaction can lead to [covalent binding] of [fluphenazine] to [peptides] and [proteins], potentially triggering [antibody formation] and ultimately contributing to [immune side effects] such as [agranulocytosis].
Navigating the Light-Sensitive Nature of Fluphenazine
This research highlights the importance of considering the [photochemical reactivity] of [fluphenazine] and its potential role in [immune side effects]. Patients taking this medication should be advised to minimize exposure to [UVA light] to mitigate the risk of [adverse reactions]. This study, like a flickering candle illuminating a dark room, sheds light on the complex interplay between [light], [drugs], and the [immune system].
Dr. Camel's Conclusion
This fascinating study, like a mirage revealing hidden truths, demonstrates the potential for [photochemical reactions] to influence [drug side effects]. The researchers' findings underscore the importance of understanding the intricate relationships between [drugs], [light], and the [immune system]. As we continue our journey through the vast desert of [pharmacology], we must remain vigilant in deciphering the complex mechanisms behind [drug reactions].
Date :
- Date Completed 2007-12-20
- Date Revised 2013-11-21
Further Info :
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