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Short-term continuous infusion of apomorphine hydrochloride for treatment of Huntington's chorea: A double blind, randomized cross-over trial.
Author: BaronePaolo, BonavitaVincenzo, De MicheleGiuseppe, Di MaioLuigi, LongoKatia, MarconiStefano, VitaleCarmine
Original Abstract of the Article :
We evaluated tolerability and the efficacy of continuous infusion of apomorphine hydrochloride on involuntary movements and mood disorder in Huntington's disease (HD) patients in a pilot, single center, double-blind, randomized, crossover, and controlled versus placebo study. Nine patients with a mo...See full text at original site
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引用元:
https://doi.org/10.1002/mds.21718
データ提供:米国国立医学図書館(NLM)
Apomorphine Hydrochloride: A Potential Treatment for Huntington's Chorea
Huntington's disease (HD), a neurodegenerative disorder, can be likened to a desert storm, causing a whirlwind of involuntary movements, known as chorea. This research explores the potential of continuous infusion of apomorphine hydrochloride in treating Huntington's chorea. The researchers conducted a pilot study, using a double-blind, randomized crossover design, to assess the tolerability and efficacy of apomorphine infusion in nine patients with a molecular diagnosis of HD. The study found that continuous infusion of apomorphine significantly reduced scores on the Unified Huntington's Disease Rating Scale (UHDRS) and the Abnormal Involuntary Movement Scale (AIMS), indicating a reduction in chorea severity. The beneficial effect of apomorphine was observed throughout the 5-day treatment period, with no significant adverse events reported. The findings suggest that continuous infusion of apomorphine may be a viable option for treating involuntary movements in some HD patients.
Apomorphine Shows Promise for Managing Chorea in HD
The study provides evidence for the potential benefits of apomorphine in managing Huntington's chorea. The findings suggest that this medication could offer relief from involuntary movements, improving quality of life for individuals with HD.
Managing Huntington's Disease: Seeking a Oasis in the Storm
If you or someone you know is living with HD, seeking comprehensive care and support is essential. Consult with a neurologist for a comprehensive evaluation and to discuss treatment options, including potential medications such as apomorphine.
Dr.Camel's Conclusion
This research delves into the potential of apomorphine hydrochloride in treating Huntington's chorea, a debilitating neurodegenerative disorder. The study suggests that continuous infusion of apomorphine may offer relief from involuntary movements, improving quality of life for individuals with HD. While further research is needed, these findings represent a promising step forward in managing this challenging condition. Just as a desert traveler seeks a cool oasis during a scorching storm, individuals with HD are searching for ways to manage their symptoms and improve their well-being. This research offers a potential oasis in the midst of the storm, providing hope for a more comfortable and fulfilling life.
Date :
- Date Completed 2008-02-20
- Date Revised 2015-11-19
Further Info :
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