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Midodrine: insidious development of urologic adverse effects in patients with spinal cord injury: a report of 2 cases.

Author: HughesPeter L, SoniBakul M, VaidyanathanSubramanian

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Overview

This study reports two cases of spinal cord injury patients who experienced urologic adverse effects after taking midodrine for postural hypotension. In both cases, midodrine caused urine retention and other complications. The study suggests that midodrine should be used with caution in patients with spinal cord injury and that other treatments should be considered if urologic side effects occur.
Paper Details　
Original Abstract of the Article :
Midodrine, a prodrug, is converted after oral administration into its active drug, desglymidodrine, which acts as an alpha(1)-adrenoceptor stimulant. Midodrine is prescribed for the treatment of neurogenic orthostatic hypotension in patients with spinal cord injury. By virtue of its alpha(1)-adrener...See full text at original site
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引用元：
https://doi.org/10.1007/BF02849965

データ提供：米国国立医学図書館（NLM）

Midodrine's Hidden Urologic Effects in Spinal Cord Injury

The world of medicine is full of surprises, especially when it comes to unexpected side effects of medications. This research sheds light on a potential complication associated with the use of midodrine, a drug commonly prescribed to treat postural hypotension in individuals with spinal cord injuries.

Midodrine Can Lead to Urinary Retention and Detrusor-Sphincter Dyssynergia

The study highlights two cases of patients with spinal cord injuries who developed urinary problems after taking midodrine. The drug, which acts as an alpha(1)-adrenoceptor stimulant, can lead to an increase in bladder sphincter tone, potentially causing urinary retention. In addition, midodrine can worsen the condition known as detrusor-sphincter dyssynergia, which disrupts the coordinated function of the bladder and sphincter muscles, leading to complications such as hydroureteronephrosis. This study reveals that midodrine might have hidden urologic side effects that require careful consideration.

Implications for Spinal Cord Injury Management

This research emphasizes the importance of monitoring patients taking midodrine for potential urologic complications, especially those with spinal cord injuries. The study underscores the need for a multi-disciplinary approach to manage these conditions, involving both neurologists and urologists to ensure optimal patient care. It also suggests that alternative treatment options for postural hypotension should be considered, particularly in individuals with spinal cord injuries.

Dr. Camel's Conclusion

Just as a thirsty traveler in the desert might seek out a hidden oasis, this research helps us uncover a hidden complication of midodrine, a drug used to treat postural hypotension. It emphasizes the importance of careful observation and prompt action to address any potential adverse effects that might arise during treatment.

Date :
  1. Date Completed 2008-01-09
  2. Date Revised 2019-11-10
Further Info :

Pubmed ID

17901021

DOI: Digital Object Identifier

10.1007/BF02849965

Related Literature

Article Analysis
・Effects of midodrine
SNS
PICO Info
in preparation
Languages

English

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