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Tolcapone: an efficacy and safety review (2007).

Author: OlanowC Warren, WatkinsPaul B

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This article reviews the safety and efficacy of tolcapone, a catechol-O-methyltransferase inhibitor, for Parkinson's disease. Tolcapone has been associated with rare, but serious, liver injury. The drug was withdrawn from the market in some countries but has been reintroduced with stricter monitoring requirements. The article concludes that tolcapone remains an effective treatment option for Parkinson's disease when used with appropriate monitoring.
Paper Details　
Original Abstract of the Article :
Tolcapone (Tasmar), an inhibitor of catechol-O-methyltransferase, is an effective antiparkinsonian agent when used as an adjunct to levodopa in patients with Parkinson disease who have end-of-dose motor fluctuations. In clinical trials, tolcapone significantly reduced "off" time and levodopa require...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/17909307

データ提供：米国国立医学図書館（NLM）

Tolcapone: A Journey Through the Desert of Parkinson's Disease

Parkinson's disease, a neurodegenerative disorder, can be a challenging journey through a desert of physical limitations. This research explores tolcapone, a drug that acts like a guide through the desert of Parkinson's symptoms, helping patients navigate the shifting sands of motor fluctuations. The researchers conducted a comprehensive review of clinical trials to evaluate the efficacy and safety of tolcapone.

Tolcapone: A Potential Oasis in the Desert of Parkinson's

The research suggests that tolcapone can be an effective treatment for Parkinson's disease, helping patients overcome the debilitating motor fluctuations. It's like finding a reliable source of water in the desert – providing a much-needed respite from the harsh realities of the disease. However, the research also highlighted the potential for liver toxicity, reminding us that even the most promising treatments can have unexpected side effects.

Navigating the Desert of Parkinson's with Caution

This research underscores the importance of careful monitoring and informed decision-making when dealing with Parkinson's disease. While tolcapone offers a potential oasis of relief, it's crucial to work closely with a healthcare professional, like a trusted desert guide, to weigh the benefits and risks of this treatment.

Dr.Camel's Conclusion

Tolcapone can offer a potential oasis of relief for those navigating the desert of Parkinson's disease. However, like a desert landscape, the path to understanding its full potential is complex and requires careful navigation, with a focus on safety and awareness.

Date :
  1. Date Completed 2008-01-09
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

17909307

DOI: Digital Object Identifier

00002826-200709000-00006

Related Literature

Article Analysis
・Side Effects of tolcapone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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