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Inhibitory effects of ginsenosides and their hydrolyzed metabolites on daunorubicin transport in KB-C2 cells.

Author: HasegawaHideo, KitagawaShuji, NabekuraTomohiro, TachikawaEiichi, TakahashiTomoharu

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that ginseng metabolite M4, which lacks a sugar moiety, increased the accumulation of daunorubicin in multidrug-resistant P-glycoprotein (P-gp)-overexpressing KB-C2 cells by 3.6-fold. Metabolites M1 and M12 also increased accumulation, but to a lesser extent. The findings suggest that metabolites without glucose moieties have a greater effect on daunorubicin transport.
Paper Details　
Original Abstract of the Article :
We studied the effects of ginsenosides and their metabolites on daunorubicin transport in multidrug-resistant P-glycoprotein (P-gp)-overexpressing KB-C2 cells. Ginsenoside Rg1, which is a protopanaxatriol-type ginseng saponin, did not have any effects on the accumulation of P-gp substrate daunorubic...See full text at original site
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引用元：
https://doi.org/10.1248/bpb.30.1979

データ提供：米国国立医学図書館（NLM）

Ginsenosides: A Potential Weapon Against Multidrug Resistance in Cancer

Cancer is a complex and challenging disease to treat, and multidrug resistance is a significant obstacle. This research explores the potential of ginsenosides, compounds found in ginseng, in overcoming multidrug resistance in cancer cells. The study investigates the effects of ginsenosides and their metabolites on the transport of daunorubicin, a chemotherapy drug, in cancer cells that overexpress P-glycoprotein (P-gp), a protein that contributes to multidrug resistance.

Ginsenosides: A Potential Solution to Multidrug Resistance

The researchers found that certain metabolites of ginsenosides, particularly those without sugar moieties, increased the accumulation of daunorubicin in cancer cells, suggesting that they could potentially overcome multidrug resistance. These findings highlight the potential of ginsenosides as a novel approach to enhancing the effectiveness of chemotherapy.

The Battle Against Multidrug Resistance: A Continuous Struggle

This research underscores the ongoing battle against multidrug resistance in cancer. Imagine a vast desert, where each grain of sand represents a unique challenge in the fight against cancer. The researchers have uncovered a potential weapon in the form of ginsenosides, offering a new strategy to combat multidrug resistance and improve the effectiveness of chemotherapy treatments.

Dr. Camel's Conclusion

This research delves into the complex world of cancer treatment and the challenge of multidrug resistance. The findings highlight the potential of ginsenosides as a novel approach to overcoming this obstacle, offering hope for more effective cancer therapies. As we continue to navigate the vast desert of cancer research, we must remain dedicated to finding innovative solutions to combat this devastating disease.

Date :
  1. Date Completed 2007-11-06
  2. Date Revised 2023-12-13
Further Info :

Pubmed ID

17917277

DOI: Digital Object Identifier

10.1248/bpb.30.1979

Related Literature

Article Analysis
・Effects of daunorubicin
SNS
PICO Info
in preparation
Languages

English

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