Paper Details

  1. Home
  2. Paper Details

Treatments for metastatic melanoma: synthesis of evidence from randomized trials.

Author: CashinRichard, Corey-LislePatricia K, EinarsonThomas R, HemelsMichiel, LuiPhilip, MachadoMárcio

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This meta-analysis found that dacarbazine generally produces poor outcomes in the treatment of advanced melanoma. Adding other therapies offers minimal clinical advantages (possibly with interferons).
Paper Details　
Original Abstract of the Article :
BACKGROUND: Advanced melanomas (non-resectable Stage-III/IV) are fatal, with few effective treatments. It remains unclear if other drugs offer improvements over the standard, dacarbazine. PURPOSE: We quantified objective response rates (Complete+Partial response) of dacarbazine versus comparators f...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.ctrv.2007.06.004

データ提供：米国国立医学図書館（NLM）

Metastatic Melanoma: Searching for Hope in a Vast Desert

Metastatic melanoma, a particularly aggressive form of skin cancer, can feel like a vast and unforgiving desert, leaving patients searching for a glimmer of hope. This research delves into the effectiveness of various treatments for metastatic melanoma, analyzing data from numerous randomized controlled trials. The study found that dacarbazine, a standard treatment for advanced melanoma, produced modest results, highlighting the need for more effective treatment options. While the addition of interferons showed some promise in improving response rates, the overall effectiveness of existing treatments remained limited. This research underscores the urgent need for new therapeutic strategies to combat this challenging disease.

A Search for Better Treatment Options

This study emphasizes the need for more effective treatment options for metastatic melanoma. The research underscores the limitations of existing treatments, highlighting the need for continued research and development of new therapies. It's like searching for a hidden oasis in a vast and barren desert, a journey that requires persistence and a relentless pursuit of solutions.

The Journey to a More Effective Treatment

This research highlights the urgency for new and more effective treatment options for metastatic melanoma. The study's findings suggest that the current landscape of treatments is inadequate, leaving patients and physicians searching for a more effective solution. It's like navigating a desert without a compass, requiring a new approach and a relentless pursuit of a more promising path.

Dr.Camel's Conclusion

This research emphasizes the urgency for new treatment options for metastatic melanoma. It's like searching for a haven in a desert, requiring innovation and dedication to find effective solutions for patients facing this challenging disease.

Date :
  1. Date Completed 2008-02-12
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

17919823

DOI: Digital Object Identifier

10.1016/j.ctrv.2007.06.004

Related Literature

Article Analysis
・Effective treatment of melanoma
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.