Contrasting effects of pseudoephedrine and papaverine in dextran sodium sulfate-induced colitis.

Author: CarterPatsy R, HarrisNorman R, MorganGeorgia A, SpecianRobert D

Paper Details 
Original Abstract of the Article :
Dextran sodium sulfate (DSS) induces submucosal arteriolar constriction that reduces blood flow to the intestine, and the relevance of this decrease in flow needs further investigation. In the present study we examined the effects of a vasoconstrictor (pseudoephedrine) and a vasodilator (papaverine)...See full text at original site
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引用元:
https://doi.org/10.1002/ibd.20303

データ提供:米国国立医学図書館(NLM)

Contrasting Effects of Vasoconstrictors and Vasodilators in Colitis

The digestive system, like a vast desert, can be susceptible to disturbances, as seen in colitis. This research investigates the effects of vasoconstrictors and vasodilators on dextran sodium sulfate (DSS)-induced colitis, a model of inflammatory bowel disease. The study aims to uncover the complex interplay between blood flow regulation and intestinal inflammation. It's like trying to understand the delicate balance of water sources and the impact of drought on a desert ecosystem.

Blood Flow and Colitis: A Complex Desert Ecosystem

The study found that pseudoephedrine, a vasoconstrictor, worsened colitis, while papaverine, a vasodilator, had a protective effect. It's like observing how a reduction in water flow in a desert can lead to desertification, while the introduction of new water sources can promote growth and regeneration.

Maintaining Balance in the Digestive Desert

This research underscores the importance of understanding the intricate mechanisms of blood flow regulation in the digestive system, particularly in the context of inflammatory conditions. It's a reminder that maintaining a delicate balance in this desert ecosystem is crucial for overall health.

Dr.Camel's Conclusion

This study sheds light on the complex relationship between blood flow and intestinal inflammation. It's like a desert explorer discovering a hidden oasis, revealing new insights into the delicate balance of life in a challenging environment. This research is a reminder that continued exploration is necessary to understand the intricate workings of the digestive system and find effective solutions for debilitating conditions like colitis.

Date :
  1. Date Completed 2008-05-15
  2. Date Revised 2018-09-13
Further Info :

Pubmed ID

17941078

DOI: Digital Object Identifier

10.1002/ibd.20303

Related Literature

SNS
PICO Info
in preparation
Languages

English

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