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The development of tolerance to drugs that suppress food intake.

Author: ChoiSujean, FernstromJohn D

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Appetite suppressants can reduce hunger and food intake but their effectiveness diminishes with chronic use. The article discusses the biological mechanisms underlying this tolerance, highlighting the need for new appetite suppressants that maintain efficacy over extended periods.
Paper Details　
Original Abstract of the Article :
Appetite suppressants have been available as weight-reducing aids for over 50 years. The first discovered was amphetamine, which was potent, but possessed undesirable side effects (it is a stimulant and elevates blood pressure). Subsequently, a variety of appetite drugs was developed, all structural...See full text at original site
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引用元：
https://doi.org/10.1016/j.pharmthera.2007.09.001

データ提供：米国国立医学図書館（NLM）

Understanding Tolerance to Appetite Suppressants

The development of tolerance to appetite suppressants is a significant challenge in the treatment of obesity. This study explores the biological mechanisms underlying this phenomenon, focusing on the reasons why appetite suppressants lose their effectiveness over time. The researchers discuss various possibilities, including receptor down-regulation and adaptive responses in the brain's appetite control circuitry.

A Challenge for Long-Term Obesity Treatment

The study emphasizes the need for further research into the development of appetite suppressants that maintain their efficacy for extended periods. Tolerance poses a barrier to long-term weight management, as the effectiveness of these drugs wanes over time. It's like trying to quench your thirst in the desert with a single sip of water; you need a sustained source of hydration to survive the journey.

Long-Term Solutions for Obesity

The study suggests that future research should prioritize the development of appetite suppressants that overcome the issue of tolerance. This is crucial for effective long-term obesity treatment. By understanding the mechanisms of tolerance, scientists can design drugs that deliver sustained benefits and support patients on their weight management journey.

Dr.Camel's Conclusion

This study brings to light the critical issue of tolerance to appetite suppressants, highlighting the need for innovative approaches to combat this phenomenon. It underscores the importance of long-term efficacy in the treatment of obesity. The quest for sustainable weight loss strategies is a journey through a challenging desert, but with continued research, we can develop effective tools to help individuals achieve their health goals.

Date :
  1. Date Completed 2008-03-11
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

17950459

DOI: Digital Object Identifier

10.1016/j.pharmthera.2007.09.001

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