Paper Details
- Home
- Paper Details
Effects of gender and moderate smoking on the pharmacokinetics and effects of the CYP1A2 substrate tizanidine.
Author: BackmanJanne T, NeuvonenPertti J, SchröderMarika T
Original Abstract of the Article :
OBJECTIVE: We studied the effects of gender and smoking on the pharmacokinetics and effects of the cytochrome P450 (CYP) 1A2 substrate tizanidine. METHODS: Seventy-one healthy young volunteers (male and female nonsmokers, male smokers) ingested 4 mg tizanidine. Plasma concentrations and pharmacodyn...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1007/s00228-007-0389-y
データ提供:米国国立医学図書館(NLM)
Gender and Smoking: Their Impact on Tizanidine's Effects
This research delves into the effects of gender and smoking on the pharmacokinetics and therapeutic effects of tizanidine, a medication used to treat muscle spasms. Tizanidine is metabolized by the liver enzyme CYP1A2, and factors like gender and smoking can influence its activity. The study explores how these factors impact the way the body processes and responds to tizanidine.The Influence of Gender and Smoking on Tizanidine Metabolism
The study reveals that smoking significantly reduces the levels of tizanidine in the bloodstream, while gender seems to have a less pronounced effect. This finding highlights the importance of considering individual factors like smoking habits when prescribing tizanidine, as it can affect the drug's effectiveness. It's like a desert traveler adjusting their journey based on the strength of the wind, adjusting tizanidine dosage based on smoking habits can improve the journey of healing.Personalized Medicine: Tailoring Treatment to Individual Needs
This research underscores the importance of personalized medicine, taking into account individual factors that can influence drug metabolism and response. This approach can help optimize treatment strategies, ensuring that patients receive the right dose of medication for their specific needs. It's like choosing the right camel for your journey across the desert, choosing the right dosage based on individual factors can ensure a smooth and successful journey towards healing.Dr.Camel's Conclusion
This research highlights the importance of considering individual factors like gender and smoking when prescribing tizanidine, as they can significantly influence the drug's metabolism and effectiveness. This study emphasizes the need for personalized medicine to optimize treatment outcomes and ensure patient safety.Date :
- Date Completed 2008-05-28
- Date Revised 2021-10-20
Further Info :
Related Literature
Article Analysis
SNS
PICO Info
in preparation
Languages
English
Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.
This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.