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Safety and efficacy of the oral direct renin inhibitor aliskiren in elderly patients with hypertension.

Author: CalvoCarlos, KeelingLucy, MöckelVolker, SatlinAndrew, VerdecchiaPaolo

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Aliskiren, a novel direct renin inhibitor, was found to be effective in lowering blood pressure in elderly patients with essential hypertension. The study found no evidence of dose-related increases in the incidence of adverse events.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: To evaluate the efficacy, safety and tolerability of aliskiren in elderly patients (> or =65 years old) with essential hypertension. METHODS: In this double-blind, multicenter study, 355 elderly patients with hypertension [office mean sitting systolic blood pressure (msSBP) > or =145-<1...See full text at original site
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引用元：
https://doi.org/10.1080/08037050701717014

データ提供：米国国立医学図書館（NLM）

Aliskiren: A Safe and Effective Renin Inhibitor for Elderly Hypertensives

This study investigates the efficacy, safety, and tolerability of aliskiren, a novel direct renin inhibitor, in elderly patients with hypertension. The study aimed to assess the impact of aliskiren on blood pressure control in this patient population, considering its potential benefits and risks. The authors emphasize the importance of safe and effective treatment options for older adults with hypertension, a common and often undertreated condition.

Aliskiren's Promise: Effective Blood Pressure Control in Elderly Patients

The results demonstrate that aliskiren effectively lowered blood pressure in elderly patients with hypertension, with no evidence of dose-related increases in adverse events. The study found that aliskiren was well-tolerated and provided similar blood pressure control to lisinopril, a standard antihypertensive medication.

A New Option for Hypertension: Tailoring Treatment to the Elderly

This research highlights the potential of aliskiren as a safe and effective treatment option for elderly patients with hypertension. The study's findings encourage the development of personalized treatment strategies that consider the specific needs of older adults, ensuring safe and effective blood pressure control.

Dr.Camel's Conclusion

This research is like discovering a new oasis in the desert, offering a safe and refreshing respite for elderly hypertensives. Aliskiren, like a cool spring, can provide effective blood pressure control without the harsh side effects. This study encourages us to be mindful of the unique needs of our older population and to continually seek new and innovative approaches to combat this common health concern.
Date :
  1. Date Completed 2008-02-12
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

18058456

DOI: Digital Object Identifier

10.1080/08037050701717014

Related Literature

Article Analysis
・Side Effects of aliskiren
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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