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Biochemotherapy for the treatment of metastatic malignant melanoma: a systematic review.

Author: , BakKate, CharetteManya, HammCaroline, PetrellaTeresa, VermaShailendra

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Biochemotherapy is not recommended for the treatment of metastatic malignant melanoma in adults due to its inconsistent benefits and high toxicity rates.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The incidence of malignant melanoma has increased in recent years. Current therapies for metastatic melanoma include chemotherapy and a variety of immunotherapeutic choices. With no established standard treatment option, the evaluation of biochemotherapy is warranted. METHODS: A systema...See full text at original site
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引用元：
https://doi.org/10.1016/j.ctrv.2007.10.003

データ提供：米国国立医学図書館（NLM）

Biochemotherapy for Metastatic Melanoma: A Systematic Review

Malignant melanoma, a type of skin cancer, can spread to other parts of the body, presenting a significant challenge for treatment. This study reviews the evidence for the effectiveness of biochemotherapy, a combination therapy that integrates chemotherapy with immunotherapy, in treating metastatic melanoma. The researchers conducted a systematic review of the literature to evaluate the efficacy and safety of this approach, analyzing randomized controlled trials and other relevant studies.

Biochemotherapy for Melanoma: Inconclusive Evidence and High Toxicity

The systematic review found that the evidence for the effectiveness of biochemotherapy in treating metastatic melanoma is inconsistent and limited. While some studies suggested a higher response rate with biochemotherapy compared to chemotherapy alone, the overall survival benefit remained unclear. Additionally, biochemotherapy is associated with significant toxicities, potentially leading to serious side effects and complications. The researchers concluded that biochemotherapy is not currently recommended as a standard treatment for metastatic melanoma.

Navigating the Desert of Melanoma Treatment: A Search for Effective Therapies

Melanoma is a challenging disease to treat, and finding effective therapies is like navigating a vast and unforgiving desert. This study explores the potential of biochemotherapy, revealing its limitations and associated toxicities. It emphasizes the ongoing need for research to develop more effective and less toxic treatments for metastatic melanoma, offering hope for a brighter future for those battling this disease.

Dr. Camel's Conclusion

This systematic review highlights the need for further research to evaluate the role of biochemotherapy in treating metastatic melanoma. While some studies suggest potential benefits, the overall evidence remains inconclusive, and the high toxicity profile raises concerns. The search for effective and safe treatments for melanoma continues, and this review emphasizes the importance of ongoing research to create a more favorable landscape for patients facing this disease.

Date :
  1. Date Completed 2008-05-20
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

18077098

DOI: Digital Object Identifier

10.1016/j.ctrv.2007.10.003

Related Literature

Article Analysis
・Effective treatment of melanoma
SNS
PICO Info
in preparation
Languages

English

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