Efficacy of the bovine antimicrobial peptide indolicidin combined with piperacillin/tazobactam in experimental rat models of polymicrobial peritonitis.

Author: AbbruzzettiAlessandra, CirioniOscar, Di MatteoFabio, GhiselliRoberto, GiacomettiAndrea, MocchegianiFederico, OrlandoFiorenza, SabaVittorio, ScaliseGiorgio, SilvestriCarmela

Paper Details 
Original Abstract of the Article :
OBJECTIVE: To investigate the efficacy of piperacillin/tazobactam combined with indolicidin in the prevention of lethality in two rat models of polymicrobial peritonitis. DESIGN: Prospective, randomized, controlled animal study. SETTING: Research laboratory in a university hospital. SUBJECTS: Adu...See full text at original site
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引用元:
https://doi.org/10.1097/01.CCM.0000292157.60632.89

データ提供:米国国立医学図書館(NLM)

Indolicidin: A Potential Antibacterial Agent for Polymicrobial Peritonitis

This study delves into the intriguing world of indolicidin, a bovine antimicrobial peptide, and its potential effectiveness in treating polymicrobial peritonitis, a serious infection of the abdominal cavity. The researchers investigated the efficacy of indolicidin alone and in combination with piperacillin/tazobactam, a common antibiotic, in two rat models of polymicrobial peritonitis.

Indolicidin Shows Promise in Combating Polymicrobial Peritonitis

The study found that indolicidin, both alone and in combination with piperacillin/tazobactam, significantly reduced bacterial growth and mortality in the rat models of polymicrobial peritonitis. This suggests that indolicidin might be a promising therapeutic agent for this challenging infection. It's like discovering a new species of camel that can withstand the harsh desert conditions and fight off dangerous predators, offering protection and resilience.

A New Weapon Against Polymicrobial Infections

The study's findings highlight the potential of indolicidin to address the growing problem of multidrug-resistant bacteria. This research could lead to the development of new and effective treatments for polymicrobial infections, a significant challenge in modern medicine. It's like finding a new and powerful weapon in the ongoing battle against the relentless forces of infection.

Dr.Camel's Conclusion

This study explores the potential of indolicidin as a novel therapeutic agent for polymicrobial peritonitis. The findings suggest that indolicidin could offer a promising new approach to treating this challenging infection. It's like discovering a hidden oasis in the vast and unforgiving desert of infectious disease, offering hope and potential for a more successful journey towards recovery.

Date :
  1. Date Completed 2008-02-12
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

18090372

DOI: Digital Object Identifier

10.1097/01.CCM.0000292157.60632.89

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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