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Efficacy of the bovine antimicrobial peptide indolicidin combined with piperacillin/tazobactam in experimental rat models of polymicrobial peritonitis.
Author: AbbruzzettiAlessandra, CirioniOscar, Di MatteoFabio, GhiselliRoberto, GiacomettiAndrea, MocchegianiFederico, OrlandoFiorenza, SabaVittorio, ScaliseGiorgio, SilvestriCarmela
Original Abstract of the Article :
OBJECTIVE: To investigate the efficacy of piperacillin/tazobactam combined with indolicidin in the prevention of lethality in two rat models of polymicrobial peritonitis. DESIGN: Prospective, randomized, controlled animal study. SETTING: Research laboratory in a university hospital. SUBJECTS: Adu...See full text at original site
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引用元:
https://doi.org/10.1097/01.CCM.0000292157.60632.89
データ提供:米国国立医学図書館(NLM)
Indolicidin: A Potential Antibacterial Agent for Polymicrobial Peritonitis
This study delves into the intriguing world of indolicidin, a bovine antimicrobial peptide, and its potential effectiveness in treating polymicrobial peritonitis, a serious infection of the abdominal cavity. The researchers investigated the efficacy of indolicidin alone and in combination with piperacillin/tazobactam, a common antibiotic, in two rat models of polymicrobial peritonitis.
Indolicidin Shows Promise in Combating Polymicrobial Peritonitis
The study found that indolicidin, both alone and in combination with piperacillin/tazobactam, significantly reduced bacterial growth and mortality in the rat models of polymicrobial peritonitis. This suggests that indolicidin might be a promising therapeutic agent for this challenging infection. It's like discovering a new species of camel that can withstand the harsh desert conditions and fight off dangerous predators, offering protection and resilience.
A New Weapon Against Polymicrobial Infections
The study's findings highlight the potential of indolicidin to address the growing problem of multidrug-resistant bacteria. This research could lead to the development of new and effective treatments for polymicrobial infections, a significant challenge in modern medicine. It's like finding a new and powerful weapon in the ongoing battle against the relentless forces of infection.
Dr.Camel's Conclusion
This study explores the potential of indolicidin as a novel therapeutic agent for polymicrobial peritonitis. The findings suggest that indolicidin could offer a promising new approach to treating this challenging infection. It's like discovering a hidden oasis in the vast and unforgiving desert of infectious disease, offering hope and potential for a more successful journey towards recovery.
Date :
- Date Completed 2008-02-12
- Date Revised 2018-12-01
Further Info :
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