Paper Details

  1. Home
  2. Paper Details

5-HT4 receptor agonists: similar but not the same.

Author: De MaeyerJ H, LefebvreR A, SchuurkesJ A J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Selective 5-HT(4) receptor agonists, like prucalopride, offer a promising treatment for gastrointestinal hypomotility disorders. They have a better safety profile compared to older non-selective agonists, minimizing potential target-unrelated side effects.
Paper Details　
Original Abstract of the Article :
5-Hydroxytryptamine(4) (5-HT(4)) receptors are an interesting target for the management of patients in need of gastrointestinal (GI) promotility treatment. They have proven therapeutic potential to treat patients with GI motility disorders. Lack of selectivity for the 5-HT(4) receptor has limited th...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1111/j.1365-2982.2007.01059.x

データ提供：米国国立医学図書館（NLM）

5-HT4 Receptor Agonists: A Journey Through the Gastrointestinal Landscape

This research examines the therapeutic potential of 5-HT4 receptor agonists for managing gastrointestinal (GI) motility disorders. 5-HT4 receptors are important targets in the GI tract, and their activation can promote gastrointestinal motility, a crucial process for food digestion and elimination. The study focuses on the development of selective 5-HT4 receptor agonists, aimed at minimizing side effects associated with older generations of these drugs. The researchers discuss the concept of ligand-directed signaling, which highlights the potential for developing drugs that specifically target specific receptors and tissues, leading to more precise and effective treatments.

Selective 5-HT4 Receptor Agonists: Unlocking the Potential of Gastrointestinal Motility

The research highlights the potential of selective 5-HT4 receptor agonists to offer a safer and more effective treatment for patients suffering from GI motility disorders. The study's findings underscore the importance of developing drugs that target specific receptors and pathways to minimize side effects and maximize therapeutic efficacy.

Navigating the World of Gastrointestinal Disorders

Gastrointestinal motility disorders can significantly impact an individual's quality of life. This research offers hope for patients by exploring the therapeutic potential of selective 5-HT4 receptor agonists. It's a reminder that research and development continue to advance, bringing new and innovative treatments to those who need them. If you are experiencing GI motility disorders, consulting with a healthcare professional is essential for receiving the best possible care.

Dr. Camel's Conclusion

This research, like a camel traversing the vast and winding paths of the GI system, uncovers the promise of selective 5-HT4 receptor agonists. The study's findings offer hope for patients seeking relief from GI motility disorders, reminding us that the pursuit of scientific knowledge often leads to breakthroughs in healthcare. Remember, if you are experiencing GI issues, seek professional advice to ensure you receive the best possible care.
Date :
  1. Date Completed 2008-05-21
  2. Date Revised 2010-11-18
Further Info :

Pubmed ID

18199093

DOI: Digital Object Identifier

10.1111/j.1365-2982.2007.01059.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.