Ketolides: pharmacological profile and rational positioning in the treatment of respiratory tract infections.

Author: HarmsJoerg M, TulkensPaul M, Van BambekeFrançoise, Van LaethemYves

Paper Details 
Original Abstract of the Article :
Ketolides differ from macrolides by removal of the 3-O-cladinose (replaced by a keto group), a 11,12- or 6,11-cyclic moiety and a heteroaryl-alkyl side chain attached to the macrocyclic ring through a suitable linker. These modifications allow for anchoring at two distinct binding sites in the 23S r...See full text at original site
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引用元:
https://doi.org/10.1517/14656566.9.2.267

データ提供:米国国立医学図書館(NLM)

Ketolides: A New Generation of Antibiotics

Bacterial infections, like persistent desert winds, can pose significant threats to human health. This study, like a team of researchers searching for new weapons against bacterial invaders, explores the pharmacological profile and potential of ketolides, a new class of antibiotics.

Ketolides: A Promising New Frontier in Antibiotic Therapy

The study, like a caravan of researchers traversing the vast desert of antibiotic research, highlights the unique features of ketolides, which differ from macrolides in their structure and mechanism of action. Ketolides demonstrate enhanced activity against erythromycin-susceptible strains, maintain activity against erythromycin-resistant strains, and possess favorable pharmacokinetic properties. These features make ketolides a promising alternative for treating severe respiratory tract infections.

Navigating the Sands of Antibiotic Resistance

This study, like a beacon of hope in the desert of antibiotic resistance, offers a potential solution to the growing problem of bacterial resistance. Ketolides, like a new breed of camels adapted to the harsh desert environment, may provide a more effective weapon against bacterial infections. However, the authors emphasize the need for continued surveillance of bacterial susceptibility to ensure the effectiveness of these drugs.

Dr.Camel's Conclusion

This study, like a well-worn caravan route through the desert of antibiotic research, reveals the potential of ketolides as a promising new class of antibiotics. These drugs, like sturdy camels navigating the treacherous sands, may offer a more effective solution to the growing problem of bacterial resistance. As we continue to explore the vast desert of antimicrobial research, we must remain vigilant in our efforts to combat the ever-evolving threats posed by bacterial infections.

Date :
  1. Date Completed 2008-04-08
  2. Date Revised 2019-09-17
Further Info :

Pubmed ID

18201149

DOI: Digital Object Identifier

10.1517/14656566.9.2.267

Related Literature

SNS
PICO Info
in preparation
Languages

English

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