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Serotonin transporter polymorphism (5-HTTLPR) and citalopram effectiveness and side effects in children with depression and/or anxiety disorders.

Author: ApterAlan, BrentDavid, CarmelMiri, FrischAmos, GothelfDoron, KronenbergSefi, MelhemNadine, PickNimrod, SchirmanShella, WeizmanAbraham

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The 5-HTTLPR ss genotype was associated with a poorer clinical response to citalopram in children and adolescents with depression and/or anxiety.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: The aim of this study was to examine the association between polymorphism in the serotonin transporter gene and citalopram effectiveness and side effects in children and adolescents with major depressive disorder (MDD) and/or anxiety disorders. METHODS: Outpatients, aged 7- 18 years with...See full text at original site
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引用元：
https://doi.org/10.1089/cap.2006.0144

データ提供：米国国立医学図書館（NLM）

The Serotonin Transporter Polymorphism and Citalopram Response: A Genetic Perspective

In the realm of [child and adolescent mental health], understanding the genetic factors that influence medication response is a critical area of research. This study investigates the association between a specific gene polymorphism, [the serotonin transporter polymorphism (5-HTTLPR)], and the effectiveness and side effects of [citalopram] in children and adolescents with [major depressive disorder (MDD)] and/or [anxiety disorders].

A Genetic Influence on Citalopram Response

The study suggests that individuals with the [5-HTTLPR ss genotype] may exhibit a less robust response to [citalopram] in terms of [depressive symptoms] compared to those with the [sl/ll genotypes]. This finding underscores the importance of considering individual genetic variations when prescribing medications for [depression] and [anxiety] in this population.

Personalized Treatment Approaches

This research highlights the potential of [genetic testing] to guide treatment decisions in [child and adolescent mental health]. Just as a camel adapts its travel plan based on the terrain, we must consider individual genetic variations when tailoring treatment approaches for this vulnerable population.

Dr.Camel's Conclusion

This study provides valuable insight into the influence of [genetic factors] on [medication response] in [child and adolescent mental health]. The authors' findings emphasize the importance of a personalized approach to treatment, reminding us that each individual's genetic makeup can shape their response to medication.
Date :
  1. Date Completed 2008-04-03
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

18315446

DOI: Digital Object Identifier

10.1089/cap.2006.0144

Related Literature

Article Analysis
・Side Effects of citalopram
SNS
PICO Info
in preparation
Languages

English

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