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Pharmacologic effects of ospemifene in rhesus macaques: a pilot study.

Author: DeGregorioMichael W, Hellmann-BlumbergUtha, WurzGregory T

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Ospemifene, a new selective estrogen receptor modulator, is being developed for the treatment of postmenopausal vulvar and vaginal atrophy. In a pilot study in rhesus macaques, ospemifene showed favorable pharmacokinetic properties and no significant haematologic toxicities or uterotrophic effects. It also did not induce DNA adducts in liver or endometrial tissues.
Paper Details　
Original Abstract of the Article :
Ospemifene (Ophena) is a new selective oestrogen receptor modulator currently in phase III clinical development for treatment of post-menopausal vulvar and vaginal atrophy. In the present study, we examined the pharmacokinetics, toxicity, and DNA adduct forming potential of ospemifene in the liver a...See full text at original site
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引用元：
https://doi.org/10.1111/j.1742-7843.2008.00235.x

データ提供：米国国立医学図書館（NLM）

Ospemifene: A Promising Treatment for Vaginal Atrophy

Vaginal atrophy, a common condition affecting postmenopausal women, can cause discomfort and impact quality of life. This research explores the pharmacokinetics, toxicity, and DNA adduct-forming potential of ospemifene, a selective estrogen receptor modulator (SERM) currently in development for treating vaginal atrophy. The study evaluated the safety and effectiveness of ospemifene in rhesus macaques, providing valuable insights into its potential as a safe and effective treatment option.

The Desert of Menopause: Finding a Solution for Vaginal Atrophy

This research delves into the challenges of managing vaginal atrophy, a common condition affecting postmenopausal women. Imagine a vast desert, where the journey can be uncomfortable and require careful navigation. This research explores the potential of ospemifene, a promising drug for treating vaginal atrophy, offering a potential oasis in the desert of menopause.

A Safe and Effective Oasis: Evaluating Ospemifene

This research explores the safety and effectiveness of ospemifene, a selective estrogen receptor modulator (SERM), for treating vaginal atrophy. The study found that ospemifene exhibited favorable pharmacokinetic properties and a low toxicity profile in rhesus macaques, suggesting potential for safe and effective treatment of vaginal atrophy. It's like finding a safe and effective oasis in the desert of menopause, where individuals can find relief from symptoms and improve their overall well-being.

Dr.Camel's Conclusion

This research provides valuable insights into the potential of ospemifene as a safe and effective treatment option for vaginal atrophy. The study's findings offer a beacon of hope for postmenopausal women seeking relief from the symptoms of vaginal atrophy, potentially improving their quality of life and overall well-being. This research, like a skilled camel guide navigating the desert of menopause, helps healthcare professionals find the most effective and compassionate treatment options for their patients.
Date :
  1. Date Completed 2008-06-12
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

18346046

DOI: Digital Object Identifier

10.1111/j.1742-7843.2008.00235.x

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・Effects of ospemifene
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PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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