In vitro and in vivo effects of 2-methoxyestradiol, either alone or combined with albendazole, against Echinococcus metacestodes.

Author: GottsteinBruno, HemphillAndrew, MüllerJoachim, NaguleswaranArunasalam, Ortega-MoraLuis M, SpicherMartin

Paper Details 
Original Abstract of the Article :
The metacestode (larval) stage of the tapeworm Echinococcus multilocularis causes alveolar echinococcosis (AE), a mainly hepatic disease characterized by continuous asexual proliferation of metacestodes by exogenous budding, resulting in the tumor-like, infiltrative growth of the parasite lesion. Cu...See full text at original site
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引用元:
https://doi.org/10.1016/j.exppara.2008.02.012

データ提供:米国国立医学図書館(NLM)

In Vitro and In Vivo Effects of 2-Methoxyestradiol Against Echinococcus Metacestodes

Alveolar echinococcosis (AE), a parasitic disease, is like a relentless desert storm, invading the body with the persistent growth of Echinococcus metacestodes. Current treatments, such as benzimidazoles, are effective in slowing the storm but not in completely eradicating it. This study explores the potential of 2-methoxyestradiol (2-ME2), a natural compound with anti-tumor properties, in combating AE. The researchers investigated the effects of 2-ME2, both alone and in combination with albendazole, a common anti-parasitic drug, on Echinococcus metacestodes. Their findings highlight the potential of 2-ME2 as a novel agent for fighting this parasitic infection, offering hope for a more effective treatment strategy.

Combating the Desert Storm of Alveolar Echinococcosis

This research demonstrates the potential of 2-ME2 in combating AE, offering a promising alternative to existing therapies. The findings suggest that 2-ME2 may have a synergistic effect with albendazole, potentially enhancing the effectiveness of treatment. Further research is needed to fully understand the mechanisms of action of 2-ME2 and to optimize its therapeutic potential in managing AE.

Navigating the Sands of Parasitic Infection

For individuals battling parasitic infections, finding a safe and effective treatment is essential. This study sheds light on the potential of 2-ME2, a natural compound with anti-tumor properties, as a novel agent for combating AE. The findings provide hope for a more effective treatment strategy, potentially offering relief from the debilitating effects of this parasitic infection. Continued research is crucial to fully understand the long-term benefits and potential side effects of 2-ME2 in treating AE, ultimately aiming to improve the lives of those affected.

Dr.Camel's Conclusion

This study provides a promising lead in the fight against AE, a challenging parasitic infection. The findings suggest that 2-ME2, a natural compound, could be a valuable weapon in combating this disease, potentially offering a more effective and well-tolerated treatment option. Further research is needed to fully explore the therapeutic potential of 2-ME2 and to develop optimal treatment strategies for AE.

Date :
  1. Date Completed 2008-07-21
  2. Date Revised 2022-04-10
Further Info :

Pubmed ID

18442817

DOI: Digital Object Identifier

10.1016/j.exppara.2008.02.012

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SNS
PICO Info
in preparation
Languages

English

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