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Effects of atazanavir/ritonavir or fosamprenavir/ritonavir on the pharmacokinetics of rosuvastatin.

Author: BainAmy M, BedimoRoger G, BustiAnthony J, HallRonald G, LeffRichard D, MeekClaudia, MehvarReza

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Rosuvastatin is a cholesterol-lowering drug, but it can interact with other medications. This study will investigate how rosuvastatin interacts with atazanavir/ritonavir or fosamprenavir/ritonavir, which are HIV medications.
Paper Details　
Original Abstract of the Article :
Rosuvastatin (RSV) is a potent statin with a lower potential for drug interactions. However, recent data have revealed unexpected increases in RSV concentrations with lopinavir/ritonavir. The objective is to study the pharmacokinetic interaction of RSV with atazanavir/ritonavir (ATV/RTV) or fosampre...See full text at original site
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引用元：
https://doi.org/10.1097/FJC.0b013e31817b5b5a

データ提供：米国国立医学図書館（NLM）

Drug Interactions: Atazanavir/Ritonavir and Rosuvastatin

Rosuvastatin (RSV) is a commonly used statin medication, but its interaction with certain HIV protease inhibitors, such as lopinavir/ritonavir, has raised concerns. This study investigates the pharmacokinetic interaction of RSV with atazanavir/ritonavir (ATV/RTV) or fosamprenavir/ritonavir (FPV/RTV). The researchers found that ATV/RTV significantly increased RSV concentrations, while FPV/RTV had a minimal impact. This research highlights the importance of carefully managing drug interactions, particularly when combining statins and protease inhibitors.

Navigating Drug Interactions: A Balancing Act

This research underscores the importance of understanding drug interactions, a critical aspect of safe and effective medication use. Similar to a camel navigating a complex desert landscape, careful consideration of potential drug interactions is essential for achieving optimal health outcomes. The study's findings highlight the need for close monitoring and potential dose adjustments when combining statins and protease inhibitors.

Drug Interactions: A Reminder of Careful Monitoring

The study emphasizes the importance of careful monitoring and potentially adjusting drug dosages when combining medications, particularly those that have the potential for interactions. It underscores the need for open communication between patients and healthcare providers to ensure that medications are used safely and effectively.

Dr. Camel's Conclusion

This study provides valuable insights into the pharmacokinetic interactions between rosuvastatin and certain HIV protease inhibitors. The findings highlight the need for careful monitoring and potential dose adjustments to ensure the safe and effective use of these medications. The research serves as a reminder of the importance of understanding and managing drug interactions to optimize patient outcomes and minimize potential risks.

Date :
  1. Date Completed 2008-10-08
  2. Date Revised 2020-12-09
Further Info :

Pubmed ID

18520949

DOI: Digital Object Identifier

10.1097/FJC.0b013e31817b5b5a

Related Literature

Article Analysis
・Effects of atazanavir
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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