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Treatment of age-associated memory impairment with guanfacine.

Author: CoffeyD J, CrookT H, JenkynL R, LarrabeeG J, McEnteeW J, PetrieW

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Guanfacine, an alpha2 adrenergic agonist, showed modest mood-improving effects but had no significant effects on learning and memory in a study of persons with age-associated memory impairment (AAMI).
Paper Details　
Original Abstract of the Article :
Alpha2 adrenergic agonists have been shown to improve memory test performance in amnesic humans and aged nonhuman primates. In a group of drugs in this class that were tested for their effects on age-related memory impairments in aged monkeys, guanfacine was the most effective for improving mnemonic...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1862205

データ提供：米国国立医学図書館（NLM）

Treatment of Age-Associated Memory Impairment with Guanfacine

This study explores the potential of [guanfacine], an [alpha2 adrenergic agonist], for treating [age-associated memory impairment (AAMI)]. The researchers investigated the effects of guanfacine on learning and memory in individuals with AAMI. Their findings provide insights into the potential of this medication for improving cognitive function in older adults.

Guanfacine: A Potential Solution for Memory Impairment?

The study's results suggest that [guanfacine] may have [modest mood-improving effects] but did not show significant effects on [learning and memory] in individuals with [AAMI]. While these findings are preliminary, they highlight the need for further research to explore the potential of guanfacine and other alpha2 adrenergic agonists for treating AAMI.

Navigating the Challenges of Age-Related Cognitive Decline

Age-related cognitive decline is a common concern for older adults. This research underscores the importance of exploring new and effective treatments to maintain cognitive function and improve the quality of life for older adults. While the study's findings did not show significant effects of guanfacine on memory, they highlight the need for continued research into potential therapies for AAMI.

Dr. Camel's Conclusion

Age-associated memory impairment can feel like a desert of forgotten thoughts. This research explores the potential of [guanfacine] as a treatment for AAMI. While the results were inconclusive, it's a reminder that the quest for treatments for cognitive decline is a long and winding path. We must continue to search for solutions that can help older adults maintain their cognitive abilities and live fulfilling lives.

Date :
  1. Date Completed 1991-09-05
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

1862205

DOI: Digital Object Identifier

1862205

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Article Analysis
・Side Effects of guanfacine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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