Real-life evaluations of compliance with mandatory drug safety monitoring exemplified with tolcapone in Parkinson's disease.

Author: EggertKarla M, OertelWolfgang H, ReeseJens P, UngerMarcus M

Paper Details 
Original Abstract of the Article :
In 1998, the European Medicines Agency suspended the approval for tolcapone in Parkinson's disease (PD) with motor complications due to the drug's implication in fulminant liver failure and the consequent death of 3 patients. Clinical data obtained by ongoing use of tolcapone in other countries prov...See full text at original site
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引用元:
https://doi.org/10.1159/000144081

データ提供:米国国立医学図書館(NLM)

Real-Life Evaluations of Tolcapone: Navigating the Desert of Drug Safety

This research ventures into the complex landscape of drug safety, highlighting the importance of rigorous monitoring to ensure patient well-being. It’s like carefully navigating a desert, where a seemingly harmless path might hold hidden dangers. The study focuses on tolcapone, a medication used to treat Parkinson's disease, and its implication in fulminant liver failure. This is like discovering a rare oasis that holds both potential benefits and hidden risks.

The European Medicines Agency initially suspended the approval of tolcapone due to its association with liver failure. However, the study highlights that with strict monitoring of liver enzymes, tolcapone can be safely used. This is like learning to identify the safe paths and avoid the treacherous ones in the desert. The study evaluates the compliance with mandatory drug safety monitoring under real-life conditions, finding that adherence to monitoring protocols is crucial for safe drug use. This is like having a reliable compass to guide you through the uncertainties of the desert.

Navigating the Desert of Drug Safety

This research emphasizes the importance of a balanced approach to drug use. It’s like navigating a desert, where both the beauty and the dangers must be considered. While medications can offer valuable benefits, it’s essential to understand their potential risks and adhere to safety guidelines.

Living Well with Medications

If you are taking any medication, it's important to talk to your doctor about potential risks and side effects. It’s like having a knowledgeable guide to navigate the desert and find the safest path. By following their recommendations and reporting any unusual symptoms, you can help ensure your safety and well-being.

Dr.Camel's Conclusion

This research reminds us that drug safety is an ongoing journey, requiring vigilance and careful monitoring. It’s like navigating a desert, where the landscape can change quickly and unexpectedly. By understanding the potential risks and benefits of medications and following safety guidelines, we can ensure that the journey is both safe and fruitful.

Date :
  1. Date Completed 2008-10-28
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

18628629

DOI: Digital Object Identifier

10.1159/000144081

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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