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Response of obstructive sleep apnea to fluoxetine and protriptyline.

Author: HanzelD A, HudgelD W, ProiaN G

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Fluoxetine, a serotonin-uptake inhibitor, was beneficial to some, but not all, patients with obstructive sleep apnea (OSA). It decreased the proportion of REM sleep time and the number of apneas or hypopneas in NREM sleep, but did not significantly improve oxygenation or arousal.
Paper Details　
Original Abstract of the Article :
Protripyline is the pharmacologic agent most commonly used to treat obstructive sleep apnea (OSA); however, its anticholinergic side effects make it intolerable to many patients. Because serotonin may be a central respiratory stimulant and because the serotonin-uptake inhibitor, fluoxetine, is usual...See full text at original site
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引用元：
https://doi.org/10.1378/chest.100.2.416

データ提供：米国国立医学図書館（NLM）

Treating Obstructive Sleep Apnea: A Comparison of Fluoxetine and Protriptyline

In the world of [sleep medicine], like a desert landscape where the silence is broken only by the rustling of sand, researchers seek ways to improve the lives of those who suffer from [obstructive sleep apnea (OSA)]. This study, like a camel navigating a treacherous sandstorm, compared the effectiveness of two medications, [fluoxetine] and [protriptyline], in treating OSA. The researchers, like desert explorers seeking a safe haven, aimed to find a medication that could effectively reduce the number of apneas and hypopneas, which are brief pauses in breathing during sleep. They discovered that both medications significantly decreased the amount of [REM sleep] time and reduced the number of apneas or hypopneas during [NREM sleep]. However, neither medication significantly improved the number of [arterial oxygen desaturation events], the severity of [arterial oxygen desaturation], or the number of [arousals] during sleep.

Seeking a Better Sleep Solution for OSA

This study, like a camel searching for a new water source, highlights the ongoing search for effective treatments for OSA. While both fluoxetine and protriptyline showed some benefits, neither medication was a complete solution. This underscores the need for continued research to develop more effective therapies for this common sleep disorder.

Understanding the Challenges of OSA

This study, like a desert oasis that faces a threat of drought, reveals the complexities of treating OSA. While medications can offer some relief, they may not be a complete solution for all patients. This emphasizes the importance of a comprehensive approach to treatment, including lifestyle modifications and other therapies, to achieve optimal outcomes for those suffering from OSA.

Dr. Camel's Conclusion

This study, like a caravan traversing a desert, provides valuable insights into the treatment of OSA. While both fluoxetine and protriptyline showed some benefits, neither medication provided a complete solution. This highlights the need for ongoing research to develop more effective therapies for OSA, as well as the importance of a multi-faceted approach to treatment, including lifestyle modifications and other therapies.
Date :
  1. Date Completed 1991-09-06
  2. Date Revised 2022-03-21
Further Info :

Pubmed ID

1864117

DOI: Digital Object Identifier

10.1378/chest.100.2.416

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・Side Effects of protriptyline
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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