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Pyridoxine supplementation for the treatment of levetiracetam-induced behavior side effects in children: preliminary results.

Author: GreenbergErica, KhanAlisa, MajorPhilippe, ThieleElizabeth A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.

Overview

This study investigated the potential benefit of pyridoxine (vitamin B6) supplementation in reducing behavioral side effects associated with levetiracetam (LEV) treatment in pediatric epilepsy patients. In 22 patients who started pyridoxine after LEV, nine (41%) experienced significant behavioral improvement, eight (36%) showed no change, four (18%) deteriorated, and one had uncertain effects. These improvements were observed within the first week of supplementation. Pyridoxine is a safe and readily available option, prompting further research to better understand its effects.
Paper Details　
Original Abstract of the Article :
Behavioral side effects related to the use of levetiracetam (LEV) in epilepsy are increasingly being recognized. Patients followed in our center have reported improvement of these side effects after starting pyridoxine (vitamin B(6)) supplements. Using mailed questionnaires, retrospective chart revi...See full text at original site
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引用元：
https://doi.org/10.1016/j.yebeh.2008.07.004

データ提供：米国国立医学図書館（NLM）

Pyridoxine Supplementation for Levetiracetam-Induced Behavioral Side Effects in Children

Pediatric neurology is a fascinating field. Like navigating a vast desert, we're constantly searching for solutions to improve the lives of our young patients. This research delves into a common challenge: behavioral side effects associated with levetiracetam, a medication used to manage epilepsy. The authors investigated whether pyridoxine (vitamin B6) supplementation could alleviate these troublesome side effects. Their approach, involving mailed questionnaires, chart reviews, and phone follow-ups, is akin to meticulously mapping out a desert oasis, ensuring the data collected is thorough and reliable.

Pyridoxine Shows Promise for Improving Behavior

The study, involving 42 pediatric patients, revealed an encouraging trend. Among patients who began taking pyridoxine after starting levetiracetam, 41% experienced significant behavioral improvements. This is a significant finding, suggesting that pyridoxine could potentially offer a safe and effective treatment option for children struggling with levetiracetam-related behavioral issues.

A Hopeful Glimpse in the Desert of Pediatric Epilepsy

For families facing the challenges of epilepsy, this research offers a glimmer of hope. The findings highlight the potential of pyridoxine as a readily available and affordable treatment. However, the study acknowledges its preliminary nature, emphasizing the need for further research. Like an intrepid explorer meticulously charting a new route, the researchers plan to conduct a placebo-controlled crossover study to provide more definitive evidence of pyridoxine's efficacy.

Dr.Camel's Conclusion

This research, like a refreshing oasis in the vast desert of pediatric epilepsy, offers a potential solution for behavioral side effects associated with levetiracetam. While further research is essential, the findings suggest pyridoxine could be a valuable tool in our quest for better treatment options for our young patients.

Date :
  1. Date Completed 2009-04-08
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

18647662

DOI: Digital Object Identifier

10.1016/j.yebeh.2008.07.004

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・Side Effects of levetiracetam
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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