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Safety of topical methimazole for the treatment of melasma. Transdermal absorption, the effect on thyroid function and cutaneous adverse effects.

Author: EshraghianA, HandjaniF, KasraeeB, NikbakhshM, OmraniG R, ParhizgarA, Safaee ArdekaniG H, SamaniM, SauratJ H, SorgO, TanidehN

Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the safety of topical methimazole, an antithyroid compound, for treating pigmented lesions. Topical methimazole has a skin-depigmenting effect but its impact on thyroid function is unknown. The study found that topical methimazole did not affect thyroid hormones, even after long-term application. It also demonstrated that topical methimazole was well-tolerated, suggesting it may be a safe option for treating skin hyperpigmentation.
Paper Details　
Original Abstract of the Article :
Methimazole is an oral antithyroid compound that exhibits a skin-depigmenting effect when used topically. However, the effect of topical methimazole on thyroid function has not been reported. This study was aimed at assessing the safety of topical methimazole used to treat pigmented lesions, without...See full text at original site
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引用元：
https://doi.org/10.1159/000148222

データ提供：米国国立医学図書館（NLM）

Topical Methimazole for Melasma: A Safe and Effective Treatment Option?

This research explores the safety and efficacy of topical methimazole, an antithyroid compound, for treating melasma, a common skin pigmentation disorder. The study aimed to determine whether topical application of methimazole could effectively depigment skin without causing systemic side effects on thyroid function. The study found that topical methimazole effectively depigmented skin without affecting thyroid function, suggesting that it could be a safe and effective treatment option for melasma.

Topical Methimazole: A Promising Treatment for Melasma

This study provides evidence for the safety and efficacy of topical methimazole, an antithyroid compound, as a treatment for melasma. The study found that topical methimazole was well-tolerated and did not affect thyroid function. These findings suggest that topical methimazole could be a safe and effective treatment option for melasma, offering a potential oasis of relief for those struggling with this common skin condition.

The Potential of Topical Treatments for Skin Pigmentation Disorders

This study demonstrates the potential of topical treatments for addressing skin pigmentation disorders like melasma. The findings suggest that topical methimazole can effectively depigment skin without causing systemic side effects. This research highlights the ongoing development of innovative and targeted treatments for various skin conditions, offering hope for those seeking safe and effective solutions.

Dr.Camel's Conclusion

This research is like discovering a hidden spring in the desert of dermatology, offering a potential solution for a common skin condition. It highlights the importance of exploring new and innovative treatment options for skin pigmentation disorders.

Date :
  1. Date Completed 2009-01-21
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

18667842

DOI: Digital Object Identifier

10.1159/000148222

Related Literature

Article Analysis
・Effects of methimazole
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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