[Two cases of patients with Parkinson's disease developing valvular heart disease while taking cabergoline].

Author: HiramotoTetuya, KikuchiAkio, OnoderaJunichi, OnoueNoriko, OumiMikio, SatoTakashi

Paper Details 
Original Abstract of the Article :
We experienced 2 patients of valvular heart disease in Parkinson's patients taking cabergoline. Patient 1 was a 79-year-old woman who began taking 4 mg cabergoline daily after being diagnosed with Parkinson's disease (PD) in June 2003. She presented with dyspnea in November 2005. The patient had car...See full text at original site
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引用元:
https://doi.org/10.5692/clinicalneurol.48.486

データ提供:米国国立医学図書館(NLM)

Cabergoline and Valvular Heart Disease in Parkinson's Disease Patients: Two Case Reports

This report presents two cases of Parkinson's disease patients who developed valvular heart disease while taking cabergoline, a dopamine agonist. The first patient experienced aortic regurgitation, tricuspid regurgitation, and mitral regurgitation, which resolved after switching to pramipexole and receiving appropriate medication. The second patient, unfortunately, developed severe heart failure and died after experiencing worsening valvular heart disease and complications, highlighting the potential risks associated with ergot-derived dopamine agonists. The authors emphasize the need for caution and regular monitoring for heart murmurs and echocardiography in Parkinson's patients receiving cabergoline.

Navigating the Risks: Monitoring for Cardiac Complications in Parkinson's Treatment

This study raises awareness about the potential for valvular heart disease in Parkinson's disease patients taking cabergoline. The authors emphasize the importance of regular monitoring for heart murmurs and echocardiography in this population. In the event of developing heart failure, prompt intervention, including discontinuation of the ergot preparation or switching to a non-ergot dopamine agonist, is crucial.

A Balancing Act: Managing Parkinson's Symptoms While Minimizing Cardiac Risks

The study highlights the delicate balance between managing Parkinson's symptoms and minimizing potential cardiac risks associated with dopamine agonist medications. Regular monitoring and close communication with a healthcare professional are essential in navigating this complex landscape. If you are taking cabergoline or other ergot-derived dopamine agonists, it is important to be aware of the potential cardiac risks and to seek immediate medical attention if you experience any concerning symptoms.

Dr. Camel's Conclusion

These case reports serve as a stark reminder of the potential cardiac risks associated with ergot-derived dopamine agonists, particularly cabergoline, in Parkinson's disease patients. Regular monitoring for heart murmurs and echocardiography, along with prompt medical intervention in case of heart failure, are crucial to minimizing these risks and ensuring patient safety.

Date :
  1. Date Completed 2008-10-02
  2. Date Revised 2019-09-17
Further Info :

Pubmed ID

18717182

DOI: Digital Object Identifier

10.5692/clinicalneurol.48.486

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SNS
PICO Info
in preparation
Languages

Japanese

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