Relative biologic effects of low-dose-rate alpha-emitting 227Th-rituximab and beta-emitting 90Y-tiuexetan-ibritumomab versus external beam X-radiation.

Author: BrulandOyvind S, DahleJostein, LarsenRoy H

Paper Details 
Original Abstract of the Article :
PURPOSE: To determine the relative biologic effects (RBE) of alpha-particle radiation from 227Th-rituximab and of beta-radiation from 90Y-tiuexetan-ibritumomab (Zevalin) compared with external beam X-radiation in the Raji lymphoma xenograft model. METHODS AND MATERIALS: Radioimmunoconjugates were a...See full text at original site
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引用元:
https://doi.org/10.1016/j.ijrobp.2008.05.029

データ提供:米国国立医学図書館(NLM)

Radioimmunoconjugates: A New Frontier in Cancer Treatment

The field of cancer treatment is constantly evolving, and this study explores the potential of radioimmunoconjugates as a novel therapeutic strategy. It compares the relative biologic effects (RBEs) of alpha-emitting 227Th-rituximab and beta-emitting 90Y-tiuexetan-ibritumomab (Zevalin) to external beam X-radiation in a Raji lymphoma xenograft model. The researchers meticulously analyze the tumor growth kinetics in response to these different radiation sources, revealing the distinct biological effects of alpha and beta particles. The study provides valuable insights into the potential of radioimmunoconjugates as targeted therapies, highlighting the importance of considering the specific characteristics of different radiation sources in optimizing treatment outcomes.

A Tale of Two Radiation Sources

This study reveals the distinct biological effects of alpha and beta particles, highlighting the potential of alpha-emitting radioimmunoconjugates as particularly effective targeted therapies. The research underscores the importance of considering the specific characteristics of different radiation sources in optimizing treatment outcomes for various cancers.

A New Oasis in the Desert of Cancer Treatment

This research opens a new horizon in the desert of cancer treatment, exploring the potential of radioimmunoconjugates as targeted therapies. It emphasizes the need for continued research and development to harness the power of these innovative approaches, ultimately seeking to improve treatment outcomes for cancer patients.

Dr.Camel's Conclusion

This study provides valuable insights into the potential of radioimmunoconjugates as targeted therapies, highlighting the importance of considering the specific characteristics of different radiation sources in optimizing treatment outcomes for various cancers.

Date :
  1. Date Completed 2008-10-06
  2. Date Revised 2016-11-24
Further Info :

Pubmed ID

18722269

DOI: Digital Object Identifier

10.1016/j.ijrobp.2008.05.029

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SNS
PICO Info
in preparation
Languages

English

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