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Effects of the HIV treatment drugs nevirapine and efavirenz on brain creatine kinase activity.

Author: FochesatoCeline M, MoreiraJeverson, RezinGislaine T, RomãoPedro R T, ScainiGiselli, StreckEmilio L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Nevirapine (NVP) and efavirenz (EFV), non-nucleoside reverse transcriptase inhibitors (NNRTIs) used for HIV infection, were found to significantly inhibit creatine kinase (CK) activity in the brains of mice. This suggests that NVP and EFV may inhibit brain CK activity, potentially contributing to their neurological adverse effects.
Paper Details　
Original Abstract of the Article :
Nevirapine (NVP) and efavirenz (EFV) are antiretroviral drugs belonging to potent class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) widely used for the treatment human immunodeficiency virus (HIV) infection. It has been demonstrated that NVP and EFV are able to cross the blood-brain ...See full text at original site
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引用元：
https://doi.org/10.1007/s11011-008-9109-2

データ提供：米国国立医学図書館（NLM）

The Brain's Energy Crisis: Exploring the Effects of HIV Treatment Drugs

The development of [antiretroviral drugs] has been a significant breakthrough in the fight against [HIV infection]. This research examines the potential [neurological side effects] associated with two widely used drugs, [nevirapine (NVP) and efavirenz (EFV)]. The researchers investigate the impact of these drugs on [brain creatine kinase (CK) activity], a key enzyme involved in [cellular energy homeostasis]. Their study aims to shed light on the potential mechanisms underlying the neurological toxicity associated with NVP and EFV.

A Closer Look at Neurological Toxicity: The Impact of HIV Treatment Drugs

The study found that both NVP and EFV significantly [inhibited CK activity] in various brain regions of mice. These findings suggest that these drugs may disrupt the brain's energy balance, potentially contributing to the neurological side effects observed in some patients. Further research is needed to confirm these findings and explore the potential implications for human health.

Navigating Treatment: A Careful Balance of Benefits and Risks

This study underscores the importance of carefully weighing the benefits and risks of antiretroviral therapy. While these drugs are essential for managing HIV infection, it is crucial to be aware of their potential side effects and to monitor patients closely for any neurological symptoms. Further research is needed to develop safer and more effective treatment options that minimize the risk of neurological complications.

Dr.Camel's Conclusion

You see, the brain is like a delicate oasis in the vast desert of our body, requiring a constant supply of energy to function properly. This study suggests that certain HIV treatment drugs could disrupt this delicate balance, leading to potential neurological side effects. As we continue to explore the complex relationship between HIV treatment and the brain, we must strive to develop therapies that protect this vital organ and ensure the overall well-being of patients.

Date :
  1. Date Completed 2009-01-09
  2. Date Revised 2020-12-09
Further Info :

Pubmed ID

18815873

DOI: Digital Object Identifier

10.1007/s11011-008-9109-2

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PICO Info
in preparation
Languages

English

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