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Protective effects of calmodulin antagonists (trifluoperazine and W-7) on hypothermic ischemic rat hearts.

Author: NakayamaY, SenooY, SugawaraE, TeramotoS

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Calmodulin antagonists, trifluoperazine and W-7, improved functional recovery and prevented CK release in isolated rat hearts exposed to hypothermic and ischemic conditions. TFP reduced leakage of lysosomal enzymes, while W-7 did not stabilize lysosomes.
Paper Details　
Original Abstract of the Article :
The cardioprotective effect of calmodulin antagonists, trifluoperazine (TFP) and N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7) was examined on the isolated rat heart exposed to hypothermic and ischemic conditions by measuring distribution of lysosomal enzymes in myocardial cells, and lea...See full text at original site
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引用元：
https://doi.org/10.18926/AMO/32210

データ提供：米国国立医学図書館（NLM）

Calmodulin Antagonists: A Protective Oasis in the Desert of Hypothermic Ischemia

Hypothermic ischemia, like a sudden sandstorm in the desert, can cause damage to the heart. This study investigated the potential of calmodulin antagonists, such as trifluoperazine (TFP) and W-7, in protecting the heart from this type of damage. The researchers found that these drugs could improve heart function and reduce damage during hypothermic ischemia. It's like finding a protective oasis that shields the heart from the harsh conditions of the desert.

Calmodulin Antagonists: A Potential Shield for the Heart

The study shows that calmodulin antagonists may offer a protective effect against hypothermic ischemia, providing a potential therapeutic avenue for protecting the heart from damage. It's like discovering a new shield that can withstand the onslaught of the desert's harsh conditions.

Further Research Needed for Clinical Application

While promising, the study emphasizes that further research is needed to fully understand the clinical implications of calmodulin antagonists in protecting the heart from hypothermic ischemia. It's like mapping out a path through the desert of research to fully understand the potential of these drugs.

Dr.Camel's Conclusion

This study provides valuable insights into the protective potential of calmodulin antagonists against hypothermic ischemia. It highlights the importance of continuing research in this area to develop new strategies for protecting the heart from damage.

Date :
  1. Date Completed 1991-10-16
  2. Date Revised 2017-10-06
Further Info :

Pubmed ID

1891973

DOI: Digital Object Identifier

10.18926/AMO/32210

Related Literature

Article Analysis
・Effects of trifluoperazine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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