Different effects of telithromycin on MUC5AC production induced by human neutrophil peptide-1 or lipopolysaccharide in NCI-H292 cells compared with azithromycin and clarithromycin.

Author: AmenomoriMisato, FujitaHanako, ImamuraYoshifumi, IshiiHiroshi, IshimotoHiroshi, KitazakiTakeshi, KohnoShigeru, MukaeHiroshi, NakayamaSeiko, SakamotoNoriho, YanagiharaKatsunori

Paper Details 
Original Abstract of the Article :
Mucus hypersecretion is a prominent feature in patients with chronic respiratory tract infections such as cystic fibrosis and diffuse panbronchiolitis, and the clinical effectiveness of macrolide antibiotics has been reported in these patients. Because human neutrophil peptide-1 (HNP-1), an antimicr...See full text at original site
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引用元:
https://doi.org/10.1093/jac/dkn427

データ提供:米国国立医学図書館(NLM)

The Mucus Maze: Exploring the Role of Macrolide Antibiotics in Respiratory Infections

The study delves into the intricate world of [mucus hypersecretion], a common feature of chronic respiratory tract infections, akin to navigating a vast and sticky desert. The researchers focus on the role of [human neutrophil peptide-1 (HNP-1)] in inducing [MUC5AC] mucin production, highlighting its importance in the pathogenesis of these infections. The study also explores the effectiveness of [macrolide antibiotics] in addressing this challenge, offering a potential oasis in the desert of respiratory disease.

A New Path Through the Mucus Maze: Macrolide Antibiotics and MUC5AC Production

The researchers found that [telithromycin] exhibited distinct effects on MUC5AC production compared to [azithromycin] and [clarithromycin], suggesting potential differences in their efficacy. This discovery could lead to more targeted treatment strategies for patients suffering from chronic respiratory tract infections.

Clearing the Mucus Path: Finding Relief from Respiratory Infections

The study provides valuable insights into the complex interplay between [HNP-1], [MUC5AC] production, and macrolide antibiotics. This research could lead to the development of more effective treatment strategies for patients with chronic respiratory tract infections, helping to clear the path to a healthier respiratory system.

Dr. Camel's Conclusion

This study offers a new perspective on the battle against chronic respiratory tract infections, highlighting the potential of macrolide antibiotics in addressing [mucus hypersecretion]. The researchers' findings could lead to the development of more targeted treatment strategies, offering a path to relief for those struggling with these debilitating infections.

Date :
  1. Date Completed 2009-01-23
  2. Date Revised 2016-11-24
Further Info :

Pubmed ID

18931390

DOI: Digital Object Identifier

10.1093/jac/dkn427

Related Literature

SNS
PICO Info
in preparation
Languages

English

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