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The confused cancer patient: a case of 5-fluorouracil-induced encephalopathy.

Author: ChengS, CheungW Y, FralickR A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This case report describes 5-FU-induced encephalopathy, manifesting as seizures and delirium, in a patient receiving oxaliplatin-containing chemotherapy. The case highlights the rare neurotoxicity associated with 5-FU and suggests that lactulose may be considered for managing neuropsychiatric complications if ammonia levels are elevated.
Paper Details　
Original Abstract of the Article :
The fluorinated pyrimidine 5-fluorouracil (5-FU) is an anticancer agent used in most adjuvant and palliative treatment regimens for colorectal cancer. Neurotoxicities are considered extremely rare side effects of 5-FU. Here, we report a case of 5-FU-induced encephalopathy, manifesting as seizures an...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582518/

データ提供：米国国立医学図書館（NLM）

5-Fluorouracil-Induced Encephalopathy: A Rare But Significant Side Effect

This case report details the occurrence of 5-fluorouracil (5-FU)-induced encephalopathy, a rare but serious neurological complication of this chemotherapy drug. The patient experienced seizures and delirium, highlighting the importance of recognizing and managing this potentially life-threatening side effect. The authors recommend lactulose as a potential treatment option for 5-FU-induced encephalopathy, particularly when ammonia levels are elevated.

5-Fluorouracil: A Double-Edged Sword in Cancer Treatment

This case report highlights the potential for 5-fluorouracil (5-FU), a common chemotherapy drug, to cause rare but serious neurological complications. The patient's experience underscores the importance of carefully monitoring patients for signs of encephalopathy, a potentially life-threatening condition characterized by seizures and delirium. This research is like a warning sign in the desert, reminding us of the potential dangers lurking beneath the surface of seemingly safe treatments.

Navigating the Desert of Cancer Treatment: Understanding the Risks of 5-Fluorouracil

This case report provides a valuable lesson in the complex landscape of cancer treatment. While 5-FU offers significant benefits in treating certain cancers, it's important to be aware of the potential for rare but serious adverse effects, such as encephalopathy. This research is like a guidebook for navigating the shifting sands of cancer treatment, helping us to make informed decisions about treatment options and closely monitor patients for potential complications.

Dr. Camel's Conclusion

This case report highlights the importance of recognizing and managing 5-FU-induced encephalopathy, a rare but potentially life-threatening complication of this chemotherapy drug. The authors recommend lactulose as a potential treatment option, particularly when ammonia levels are elevated.

Date :
  1. Date Completed 2010-01-22
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

19008998

DOI: Digital Object Identifier

PMC2582518

Related Literature

Article Analysis
・Side Effects of lactulose
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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