Paper Details

  1. Home
  2. Paper Details

Contribution of forebrain noradrenaline innervation to the central circulatory effects of alpha-methyldopa and 6-hydroxydopamine.

Author: HeadG A, KornerP I, van den BuuseM

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Chronic lesions of the ascending noradrenergic projections to the forebrain abolished the bradycardia produced by intracisternal alpha-methyldopa and 6-hydroxydopamine in rabbits with intact baroreceptors, suggesting that these pathways are important for the cardiac responses dependent on baroreceptor input.
Paper Details　
Original Abstract of the Article :
We studied the circulatory effects of chronic lesions of the ascending noradrenergic (NA) projections to the forebrain on the acute effects of intracisternal (i.c.) alpha-methyldopa (alpha-MD) and 6-hydroxydopamine (6-OHDA) on mean arterial pressure (MAP) and heart rate (HR) in conscious rabbits wit...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/0006-8993(91)91031-u

データ提供：米国国立医学図書館（NLM）

Forebrain Noradrenaline and Circulatory Effects: A Journey Through the Desert of Neurotransmission

The intricate world of neurotransmission is a vast desert, filled with complex pathways and interconnected systems. This research explores the role of forebrain noradrenaline (NA) innervation in regulating cardiovascular function. The researchers investigated the effects of chronic lesions of the ascending NA projections to the forebrain on the circulatory effects of alpha-methyldopa and 6-hydroxydopamine, both of which influence NA release. Their findings suggest that the ascending NA pathways play a crucial role in mediating the cardiac responses dependent on baroreceptor input.

The Shifting Sands of Neurotransmitter Influence

This study highlights the complex interplay between the nervous system and cardiovascular function. The researchers discovered that the ascending NA pathways are essential for mediating the cardiac responses to changes in blood pressure, emphasizing the crucial role of neurotransmitters in regulating cardiovascular homeostasis.

Navigating the Desert Oasis of Cardiovascular Health

This research deepens our understanding of the intricate mechanisms that regulate cardiovascular function. It underscores the importance of the nervous system and neurotransmitter signaling in maintaining a healthy cardiovascular system. Further research is needed to fully elucidate the complex interplay between the nervous system and cardiovascular function, potentially leading to novel therapeutic targets for cardiovascular diseases.

Dr. Camel's Conclusion

Just as a camel relies on its internal mechanisms to navigate the harsh desert environment, our cardiovascular system depends on the intricate balance of neurotransmitters. This study sheds light on the crucial role of forebrain noradrenaline innervation in regulating cardiovascular function, emphasizing the importance of understanding these complex processes for maintaining optimal health.

Date :
  1. Date Completed 1991-08-01
  2. Date Revised 2019-06-13
Further Info :

Pubmed ID

1905177

DOI: Digital Object Identifier

10.1016/0006-8993(91)91031-u

Related Literature

Article Analysis
・Effects of methyldopa
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.