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Appetite suppressants, cardiac valve disease and combination pharmacotherapy.

Author: BaumannMichael H, RothmanRichard B

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Obesity and drug addiction both involve dysregulation of biogenic amine neuron systems in the brain. This review discusses the neurochemical mechanisms of stimulant medications used in obesity treatment and highlights the potential for combination pharmacotherapy to yield effective and safe antiobesity medications.
Paper Details　
Original Abstract of the Article :
The prevalence of obesity in the United States is a major health problem associated with significant morbidity, mortality, and economic burden. Although obesity and drug addiction are typically considered distinct clinical entities, both diseases involve dysregulation of biogenic amine neuron system...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/19092640

データ提供：米国国立医学図書館（NLM）

Combating Obesity: A Journey Through the Brain's Chemical Landscape

This study delves into the complex world of obesity and its pharmacological treatments, exploring the neurochemical mechanisms of stimulant medications used in weight management. The researchers focus on the potential role of serotonin 2B receptors in fenfluramine-associated cardiac valvulopathy, a rare but serious side effect of certain weight-loss drugs.

This research is highly relevant, considering the global obesity epidemic and the ongoing search for safe and effective medications.

A New Approach to Obesity Treatment: Combination Pharmacotherapy

The researchers propose that targeting multiple neurochemical mechanisms with combination pharmacotherapy could lead to more effective anti-obesity medications with reduced side effects. This approach is akin to finding a multi-faceted oasis in the desert, offering multiple sources of relief and sustenance.

Navigating the Landscape of Obesity Treatment: Dr. Camel's Tips

Navigating the world of weight-loss medication can be confusing, like traversing a vast, sandy desert. This study emphasizes the need for a multi-faceted approach to combat obesity. Consult with your physician to explore the latest treatment options and identify the best approach for your individual needs.

Dr.Camel's Conclusion

This study, like a compass guiding us through the intricate terrain of obesity treatment, offers insights into the potential of combination pharmacotherapy. By targeting multiple neurochemical pathways, we may be able to create more effective and safer anti-obesity medications, ultimately leading to a healthier future for individuals struggling with this complex condition.

Date :
  1. Date Completed 2009-09-21
  2. Date Revised 2021-10-28
Further Info :

Pubmed ID

19092640

DOI: Digital Object Identifier

NIHMS85810

Related Literature

Article Analysis
・Side Effects of fenfluramine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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