Conjunctival tissue pharmacokinetic properties of topical azithromycin 1% and moxifloxacin 0.5% ophthalmic solutions: a single-dose, randomized, open-label, active-controlled trial in healthy adult volunteers.

Author: O'BrienTerrence P, TorkildsenGail

Paper Details 
Original Abstract of the Article :
Effective ocular tissue concentrations and prolonged residence times of antibacterial agents are important in treating both acute and chronic diseases. Conjunctival biopsy allows the determination of specific tissue concentration data for topical ophthalmic agents. Drug concentration analysis at var...See full text at original site
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引用元:
https://doi.org/10.1016/j.clinthera.2008.10.020

データ提供:米国国立医学図書館(NLM)

Conjunctival Tissue Pharmacokinetic Properties of Topical Azithromycin 1% and Moxifloxacin 0.5% Ophthalmic Solutions

This research explores the pharmacokinetic properties of topical azithromycin 1% and moxifloxacin 0.5% ophthalmic solutions in the conjunctival tissue. The study, a [single-dose, randomized, open-label, active-controlled trial] involving [healthy adult volunteers], aimed to investigate the drug concentrations and residence times in the conjunctival tissue after a single dose. The authors found that both azithromycin and moxifloxacin achieved effective concentrations in the conjunctival tissue, with prolonged residence times. These findings suggest that both drugs are suitable for treating both acute and chronic ocular infections.

Effective Treatment for Ocular Infections

The study demonstrates that both azithromycin 1% and moxifloxacin 0.5% ophthalmic solutions can achieve effective concentrations in the conjunctival tissue, potentially providing effective treatment for ocular infections. The prolonged residence times of these drugs suggest that they can maintain therapeutic concentrations for a sustained period, potentially leading to fewer dosing frequencies. It's like finding a permanent spring in the desert, providing a consistent and reliable source of healing for those battling ocular infections.

Navigating the Challenges of Ocular Infections

This research provides valuable insights into the treatment of ocular infections. The study's findings highlight the potential of azithromycin and moxifloxacin as effective and well-tolerated options for treating both acute and chronic ocular infections. It's like discovering a new and efficient path through the desert, offering a smoother and more effective route for managing these challenging conditions.

Dr. Camel's Conclusion

This study reveals the effectiveness of both azithromycin 1% and moxifloxacin 0.5% ophthalmic solutions in achieving therapeutic concentrations in the conjunctival tissue. The findings suggest that these drugs are suitable for treating both acute and chronic ocular infections. It's like finding a hidden oasis in the desert, offering a source of relief and healing for those struggling with ocular infections.

Date :
  1. Date Completed 2009-02-23
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

19108788

DOI: Digital Object Identifier

10.1016/j.clinthera.2008.10.020

Related Literature

SNS
PICO Info
in preparation
Languages

English

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